当前位置：
X-MOL 学术
›
J. Clin. Invest.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Randomized controlled trial of fractionated laser resurfacing on aged skin as prophylaxis against actinic neoplasia
The Journal of Clinical Investigation ( IF 15.9 ) Pub Date : 2021 , DOI: 10.1172/jci150972 Dan F Spandau 1, 2, 3 , Roy Chen 4 , Jeffrey J Wargo 5 , Craig A Rohan 4, 5 , David Southern 2 , Angela Zhang 2 , Mathew Loesch 2 , Jonathan Weyerbacher 2 , Sunil S Tholpady 3, 6 , Davina A Lewis 2 , Matthew Kuhar 2, 7 , Kenneth Y Tsai 8 , Amber J Castellanos 4 , Michael G Kemp 4 , Michael Markey 5 , Elizabeth Cates 4 , Amy R Williams 4 , Christina Knisely 4 , Sabina Bashir 4 , Ryan Gabbard 4 , Robert Hoopes 4 , Jeffrey B Travers 4, 9, 10
The Journal of Clinical Investigation ( IF 15.9 ) Pub Date : 2021 , DOI: 10.1172/jci150972 Dan F Spandau 1, 2, 3 , Roy Chen 4 , Jeffrey J Wargo 5 , Craig A Rohan 4, 5 , David Southern 2 , Angela Zhang 2 , Mathew Loesch 2 , Jonathan Weyerbacher 2 , Sunil S Tholpady 3, 6 , Davina A Lewis 2 , Matthew Kuhar 2, 7 , Kenneth Y Tsai 8 , Amber J Castellanos 4 , Michael G Kemp 4 , Michael Markey 5 , Elizabeth Cates 4 , Amy R Williams 4 , Christina Knisely 4 , Sabina Bashir 4 , Ryan Gabbard 4 , Robert Hoopes 4 , Jeffrey B Travers 4, 9, 10
Affiliation
BACKGROUND. The loss of insulin-like growth factor 1 (IGF-1) expression in senescent dermal fibroblasts during aging is associated with an increased risk of nonmelanoma skin cancer (NMSC). We tested how IGF-1 signaling can influence photocarcinogenesis during chronic UVB exposure to determine if fractionated laser resurfacing (FLR) of aged skin, which upregulates dermal IGF-1 levels, can prevent the occurrence of actinic keratosis (AK) and NMSC.
中文翻译：
老化皮肤分段激光换肤预防光化性肿瘤的随机对照试验
背景。衰老过程中衰老真皮成纤维细胞中胰岛素样生长因子 1 (IGF-1) 表达的丧失与非黑色素瘤皮肤癌 (NMSC) 风险增加相关。我们测试了慢性 UVB 暴露期间 IGF-1 信号如何影响光致癌作用，以确定老化皮肤的分段激光换肤 (FLR) 是否可以上调真皮 IGF-1 水平，从而预防光化性角化病 (AK) 和 NMSC 的发生。
更新日期：2021-10-02
中文翻译：
老化皮肤分段激光换肤预防光化性肿瘤的随机对照试验
背景。衰老过程中衰老真皮成纤维细胞中胰岛素样生长因子 1 (IGF-1) 表达的丧失与非黑色素瘤皮肤癌 (NMSC) 风险增加相关。我们测试了慢性 UVB 暴露期间 IGF-1 信号如何影响光致癌作用，以确定老化皮肤的分段激光换肤 (FLR) 是否可以上调真皮 IGF-1 水平，从而预防光化性角化病 (AK) 和 NMSC 的发生。
京公网安备 11010802027423号