Journal of Evolutionary Biochemistry and Physiology ( IF 0.6 ) Pub Date : 2021-08-24 , DOI: 10.1134/s0022093021040116 T. L. Nemirovskaya 1
Abstract
Various forms of muscle unloading can be found in patients with prolonged bed rest, with strokes and spinal lesions, during muscle immobilization in traumatology, under zero gravity, etc. During unloading, postural muscles (for example, m. soleus) are mainly affected. The rearrangement of skeletal muscles during unloading is based on their atrophy due to an increase in proteolysis and a decrease in the intensity of protein synthesis [1, 2]. The review is devoted to the study of the role of histone deacetylases I and IIa (HDAC1, HDAC4/5), as well as the p38 MAPK signaling pathway, in the activation of FoxO and myogenin transcription factors involved in the expression of atrogin-1 and MuRF-1 genes encoding E3 ubiquitin ligases under skeletal muscle unloading conditions.
中文翻译:
组蛋白去乙酰化酶 I 和 IIa(HDAC1、HDAC4/5)和 MAPK38 信号通路在骨骼肌卸载下萎缩过程的调节中的作用
摘要
长期卧床、中风和脊柱病变患者、外伤科肌肉固定、零重力等情况下,可以发现各种形式的肌肉卸载。在卸载过程中,主要影响姿势肌肉(例如比目鱼肌)。卸载过程中骨骼肌的重排是基于它们的萎缩,这是由于蛋白水解增加和蛋白质合成强度降低 [1, 2]。该综述致力于研究组蛋白去乙酰化酶 I 和 IIa(HDAC1、HDAC4/5)以及 p38 MAPK 信号通路在 FoxO 和肌细胞生成素转录因子的激活中的作用,这些转录因子参与了atrogin-1的表达和MuRF-1 在骨骼肌卸载条件下编码 E3 泛素连接酶的基因。