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Molecular and Functional Heterogeneity of Na,K-ATPase in the Skeletal Muscle
Journal of Evolutionary Biochemistry and Physiology ( IF 0.6 ) Pub Date : 2021-08-24 , DOI: 10.1134/s0022093021040086
V. V. Kravtsova 1 , I. I. Krivoi 1
Affiliation  

Abstract

Na,K-ATPase activity is critical for maintaining electrogenesis, contractile function and skeletal muscle performance. This review is devoted to the analysis of the results of recent studies in the field of molecular and functional diversity of Na,K-ATPase in skeletal muscles, which co-express α1 and α2 isoforms of the catalytic and transport Na,K-ATPase α subunit. The issues that seem to be most promising in terms of their further development are considered. The available facts indicate that, in contrast to the α1 isoform that demonstrates functional stability, the α2 isoform is distinguished by a high degree of plasticity, which is due to its specific membrane localization, functional and molecular interactions with the protein and lipid environment, as well as the peculiarities of its regulation by various factors. Functional disorders of the Na,K-ATPase α2 isoform are among the most common signs characteristic of both chronic and short-term forms of motor dysfunction.



中文翻译:

骨骼肌中 Na,K-ATPase 的分子和功能异质性

摘要

Na,K-ATPase 活性对于维持生电、收缩功能和骨骼肌性能至关重要。本综述致力于分析骨骼肌中 Na,K-ATPase 分子和功能多样性领域的最新研究结果,该酶共表达催化和转运 Na,K-ATPase α 的 α1 和 α2 异构体。亚基。考虑了在进一步发展方面似乎最有希望的问题。现有事实表明,与表现出功能稳定性的 α1 同种型相比,α2 同种型具有高度的可塑性,这是由于其特定的膜定位、与蛋白质和脂质环境的功能和分子相互作用,如以及其受各种因素调节的特殊性。

更新日期:2021-08-25
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