Using nanosized metal substrates, surface-enhanced Raman scattering (SERS) is a tool for improving the Raman signal of biomolecules. For detection, SERS has gained much popularity and an important role in determining chemical composition. In the present study, SERS spectra of 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine (olanzapine) (MPTB) were investigated on silver and silver-gold metal substrates (SERSitive, Warsaw, Poland) at different concentrations. Also, different chemical and electronic properties are investigated using DFT calculations. The ring and other functional modes in SERS change in frequency values with variations in intensity for all concentrations. The molecule is oriented in a tilted manner with respect to Ag and Ag-Au.

使用纳米金属基材，表面增强拉曼散射 (SERS) 是一种改善生物分子拉曼信号的工具。在检测方面，SERS 已广受欢迎，并在确定化学成分方面发挥重要作用。在本研究中，2-甲基-4-(4-甲基哌嗪-1-基)-10 H-噻吩并[2,3-b][1,5]苯二氮卓（奥氮平）(MPTB) 的SERS 光谱在不同浓度的银和银-金金属基材（SERSitive，Warsaw，Poland）。此外，使用 DFT 计算研究了不同的化学和电子特性。SERS 中的环和其他功能模式的频率值随所有浓度的强度变化而变化。分子以相对于 Ag 和 Ag-Au 的倾斜方式取向。