Analytical and Bioanalytical Chemistry ( IF 4.3 ) Pub Date : 2021-08-24 , DOI: 10.1007/s00216-021-03596-x Juliana Barreto Ferreira 1 , Clebson de Jesus Macrino 1 , Laíse Aparecida Fonseca Dinali 2 , João Francisco Allochio Filho 1, 3, 4 , Camilla Fonseca Silva 2 , Keyller Bastos Borges 2 , Wanderson Romão 1, 4, 5
Molecularly imprinted polymers (MIP) consist of a molecular recognition technology with applicability in different areas, including forensic chemistry. Among the forensic applications, the use of MIP in biological fluid analysis has gained prominence. Biological fluids are complex samples that generally require a pre-treatment to eliminate interfering agents to improve the results of the analyses. In this review, we address the development of this molecular imprinting technology over the years, highlighting the forensic applications of molecularly imprinted polymers in biological sample preparation for analysis of stimulant drugs such as cocaine, amphetamines, and nicotine.
Graphical abstract
中文翻译:
分子印迹聚合物作为生物样品法医应用的选择性吸附剂——综述
分子印迹聚合物 (MIP) 由一种分子识别技术组成,适用于不同领域,包括法医化学。在法医应用中,MIP 在生物体液分析中的使用已获得突出地位。生物体液是复杂的样品,通常需要进行预处理以消除干扰物以改善分析结果。在这篇综述中,我们讨论了这种分子印迹技术多年来的发展,重点介绍了分子印迹聚合物在生物样品制备中的法医应用,用于分析兴奋剂药物,如可卡因、苯丙胺和尼古丁。