ABSTRACT

Background

It remains widely accepted that spontaneous recovery from aphasia is largely limited to the first related factors. This has direct implications for acute and chronic interventions for aphasia. few months following stroke. A few recent studies challenge this view, revealing that some individuals’ language abilities improve even during the chronic stage.

Aims

To identify prognostic indicators of long-term aphasia recovery.

Methods & Procedures

Eighteen people with aphasia initially evaluated in the chronic stage were retested at least one year later. The Western Aphasia Battery-Revised (WAB-R) Aphasia Quotient (AQ) was used to quantify changes in language impairment. Prognostic factors included those related to the patient (demographic, psychosocial), stroke (lesion volume and location), and treatment (medical, rehabilitative).

Outcomes & Results

Twelve participants improved and 6 remained stable or declined. Linear regression analysis revealed that lesion volume predicted long-term language gains, with smaller lesions yielding greater improvements. Individuals who did not improve were more likely to have lesions encompassing critical frontal and temporoparietal cortical regions and interconnecting white matter pathways. Exploratory regression analysis of psychosocial and treatment-related factors revealed a positive relationship between improvement and satisfaction with life participation, and a negative relationship between improvement and perceived impairment severity. Critically, psychosocial and treatment-related factors significantly improved model fit over lesion volume, suggesting that these factors add predictive value to determining long-term aphasia prognosis.

Conclusions

Long-term aphasia recovery is multidetermined by a combination of stroke-, psychosocial-, and treatment-related factors. This has direct implications for acute and chronic interventions for aphasia.

中文翻译：

---

预测中风后失语症长期恢复的因素

摘要

背景

人们仍然普遍认为，失语症的自发恢复主要限于第一相关因素。这对失语症的急性和慢性干预有直接影响。中风后几个月。最近的一些研究挑战了这一观点，揭示了一些人的语言能力即使在慢性阶段也会有所提高。

宗旨

确定长期失语恢复的预后指标。

方法与程序

最初在慢性阶段评估的 18 名失语症患者至少在一年后接受了重新测试。Western Aphasia Battery-Revised (WAB-R) Aphasia Quotient (AQ) 用于量化语言障碍的变化。预后因素包括与患者（人口统计学、社会心理）、中风（病变体积和位置）和治疗（医疗、康复）相关的因素。

结果与结果

12 名参与者有所改善，6 名保持稳定或下降。线性回归分析显示，病变体积预测长期语言增益，较小的病变产生较大的改善。没有改善的个体更有可能出现病变，包括关键的额叶和颞顶皮质区域以及相互连接的白质通路。对社会心理和治疗相关因素的探索性回归分析表明，改善与生活参与满意度之间存在正相关关系，而改善与感知损伤严重程度之间存在负相关关系。至关重要的是，社会心理和治疗相关因素显着改善了模型对病变体积的拟合，表明这些因素增加了预测价值，以确定长期失语症的预后。

结论

长期失语症的恢复是由中风、社会心理和治疗相关因素共同决定的。这对失语症的急性和慢性干预有直接影响。