Chlorphenesin is an approved biocide frequently used in cosmetics, and its carbamate ester is an approved skeletal muscle relaxant in certain countries for the treatment of discomfort related to skeletal muscle trauma and inflammation. A major urinary metabolite is 4-chlorophenoxy acetic acid (4-CPA), also known as para-chlorophenoxyacetate, which is also employed as a target analyte in sports drug testing to detect the use of the prohibited nootropic stimulant meclofenoxate. To distinguish between 4-CPA resulting from chlorphenesin, chlorphenesin carbamate, and meclofenoxate, urinary metabolite profiles of chlorphenesin after legitimate use were investigated.

中文翻译：

---

皮肤施用含氯苯酚的防晒霜后观察到的氯苯酚尿代谢物谱的色谱-质谱分析

Chlorphenesin 是一种经批准的生物杀灭剂，常用于化妆品中，其氨基甲酸酯是某些国家批准的骨骼肌松弛剂，用于治疗与骨骼肌创伤和炎症相关的不适。一种主要的尿代谢物是 4-氯苯氧乙酸 (4-CPA)，也称为对氯苯氧乙酸，它也被用作运动药物测试中的目标分析物，以检测禁用的促兴奋剂甲氯芬酸的使用。为了区分由氯苯那新、氯苯新氨基甲酸酯和甲氯芬酯产生的 4-CPA，对合法使用后氯苯新的尿代谢物谱进行了调查。