Primary cilia, antenna-like structures of the plasma membrane, detect various extracellular cues and transduce signals into the cell to regulate a wide range of functions. Lipid rafts, plasma membrane microdomains enriched in cholesterol, sphingolipids and specific proteins, are also signalling hubs involved in a myriad of physiological functions. Although impairment of primary cilia and lipid rafts is associated with various diseases, the relationship between primary cilia and lipid rafts is poorly understood. Here, we review a newly discovered interaction between primary cilia and lipid raft dynamics that occurs during Akt signalling in adipogenesis. We also discuss the relationship between primary cilia and lipid raft-mediated Akt signalling in cancer biology. This review provides a novel perspective on primary cilia in the regulation of lipid raft dynamics.

初级纤毛，质膜的天线样结构，检测各种细胞外信号并将信号转导到细胞中以调节广泛的功能。脂筏、质膜微结构域富含胆固醇、鞘脂和特定蛋白质，也是涉及无数生理功能的信号中枢。尽管初级纤毛和脂筏的损伤与多种疾病有关，但初级纤毛和脂筏之间的关系却知之甚少。在这里，我们回顾了一个新发现的初级纤毛和脂筏动力学之间的相互作用，该相互作用发生在脂肪生成的 Akt 信号传导过程中。我们还讨论了癌症生物学中初级纤毛和脂筏介导的 Akt 信号之间的关系。