Abstract

Background

Opioid use has the potential to influence infectious respiratory diseases. The purpose of this research is to examine if there is an association of deaths from the respiratory infection, COVID-19, and unhealthy opioid use in older adults.

Methods

Data about patients, ages ≥65 years, who had a COVID-19 infection between 1/20/2020 to 12/23/2020 (n = 533,153) were extracted using the TriNetX system. Mortality incidence between initial diagnosis and ninety days after contracting COVID-19 were determined. Comparisons were made between people with and without unhealthy opioid use.

Results

There were 7,547 COVID-19 patients with unhealthy opioid use (mean age, 71.8 years; standard deviation 6.3 years) and 525,606 COVID-19 patients (mean age, 74.1 years; standard deviation 7.3 years) without unhealthy opioid use. Of the total, 15,852 (3.0%) died within 3 months of COVID-19 diagnosis. The unadjusted risk ratio of the cohort with unhealthy opioid use compared with the cohort that did not have unhealthy opioid uses was 1.18 (95% CI: 1.05,1.33); p = 0.0069. The relationship failed to remain significant in analysis with propensity score matching (risk ratio = 0.96; 95% CI: 0.82, 1.14; p = 0.6606, ns).

Conclusion

The public health implication is that although older adults are more vulnerable to COVID-19 than younger adults, a difference between older adults with or without unhealthy opioid use did not increase vulnerability to death from COVID-19 and should be not be considered if rationing of care becomes necessary.

中文翻译：

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老年人不健康的阿片类药物使用和 COVID-19 死亡率：一项多中心研究网络研究

摘要

背景

阿片类药物的使用有可能影响传染性呼吸道疾病。这项研究的目的是检查老年人因呼吸道感染、COVID-19 和不健康的阿片类药物使用而导致的死亡是否存在关联。

方法

使用 TriNetX 系统提取了有关 在 2020 年 1 月 20 日至 2020 年 12 月 23 日（n  =  533,153）之间感染 COVID-19 的患者（年龄≥65岁）的数据。确定了初始诊断和感染 COVID-19 后 90 天之间的死亡率。对使用和不使用不健康阿片类药物的人进行了比较。

结果

有 7,547 名 COVID-19 患者使用不健康的阿片类药物（平均年龄 71.8 岁；标准差 6.3 岁）和 525,606 名 COVID-19 患者（平均年龄 74.1 岁；标准差 7.3 岁）没有使用不健康的阿片类药物。其中，15,852 人（3.0%）在 COVID-19 诊断后的 3个月内死亡。与没有不健康使用阿片类药物的队列相比，使用不健康阿片类药物的队列的未调整风险比为 1.18（95% CI：1.05,1.33）；p  =  0.0069。在倾向评分匹配的分析中，这种关系未能保持显着性（风险比 = 0.96；95% CI：0.82，1.14 ；p  =  0.6606，ns）。

结论

公共卫生含义是，尽管老年人比年轻人更容易感染 COVID-19，但老年人使用或不使用不健康阿片类药物之间的差异并未增加因 COVID-19 死亡的脆弱性，如果配给护理变得必要。