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The role of Wnt signaling in skin fibrosis
Medicinal Research Reviews ( IF 13.3 ) Pub Date : 2021-08-24 , DOI: 10.1002/med.21853 Michelle F Griffin 1 , Julika Huber 1 , Fahy J Evan 1 , Natalina Quarto 1, 2 , Michael T Longaker 1, 2
Medicinal Research Reviews ( IF 13.3 ) Pub Date : 2021-08-24 , DOI: 10.1002/med.21853 Michelle F Griffin 1 , Julika Huber 1 , Fahy J Evan 1 , Natalina Quarto 1, 2 , Michael T Longaker 1, 2
Affiliation
Skin fibrosis is the excessive deposition of extracellular matrix in the dermis. Cutaneous fibrosis can occur following tissue injury, including burns, trauma, and surgery, resulting in scars that are disfiguring, limit movement and cause significant psychological distress for patients. Many molecular pathways have been implicated in the development of skin fibrosis, yet effective treatments to prevent or reverse scarring are unknown. The Wnt signaling pathways are known to play an important role in skin homeostasis, skin injury, and in the development of fibrotic skin diseases. This review provides a detailed overview of the role of the canonical Wnt signaling pathways in regulating skin scarring. We also discuss how Wnt signaling interacts with other known fibrotic molecular pathways to cause skin fibrosis. We further provide a summary of the different Wnt inhibitor types available for treating skin scarring. Understanding the role of the Wnt pathway in cutaneous fibrosis will accelerate the development of effective Wnt modulators for the treatment of skin fibrosis.
中文翻译:
Wnt信号在皮肤纤维化中的作用
皮肤纤维化是真皮中细胞外基质的过度沉积。皮肤纤维化可能发生在组织损伤后,包括烧伤、外伤和手术,导致疤痕毁容、限制活动并给患者带来严重的心理困扰。许多分子途径与皮肤纤维化的发展有关,但预防或逆转瘢痕形成的有效治疗方法尚不清楚。已知 Wnt 信号通路在皮肤稳态、皮肤损伤和纤维化皮肤病的发展中起重要作用。本综述详细概述了经典 Wnt 信号通路在调节皮肤瘢痕形成中的作用。我们还讨论了 Wnt 信号如何与其他已知的纤维化分子途径相互作用导致皮肤纤维化。我们进一步总结了可用于治疗皮肤疤痕的不同 Wnt 抑制剂类型。了解 Wnt 通路在皮肤纤维化中的作用将加速开发用于治疗皮肤纤维化的有效 Wnt 调节剂。
更新日期:2021-08-24
中文翻译:
Wnt信号在皮肤纤维化中的作用
皮肤纤维化是真皮中细胞外基质的过度沉积。皮肤纤维化可能发生在组织损伤后,包括烧伤、外伤和手术,导致疤痕毁容、限制活动并给患者带来严重的心理困扰。许多分子途径与皮肤纤维化的发展有关,但预防或逆转瘢痕形成的有效治疗方法尚不清楚。已知 Wnt 信号通路在皮肤稳态、皮肤损伤和纤维化皮肤病的发展中起重要作用。本综述详细概述了经典 Wnt 信号通路在调节皮肤瘢痕形成中的作用。我们还讨论了 Wnt 信号如何与其他已知的纤维化分子途径相互作用导致皮肤纤维化。我们进一步总结了可用于治疗皮肤疤痕的不同 Wnt 抑制剂类型。了解 Wnt 通路在皮肤纤维化中的作用将加速开发用于治疗皮肤纤维化的有效 Wnt 调节剂。