Precision surface engineering is key to advanced biomaterials. A new platform of PEGylated styrene–maleic acid copolymers for adsorptive surface biofunctionalization is reported. Balanced amphiphilicity renders the copolymers water-soluble but strongly affine for surfaces. Fine-tuning of their molecular architecture provides control over adsorptive anchorage onto specific materials—which is why they are referred to as “anchor polymers” (APs)—and over structural characteristics of the adsorbed layers. Conjugatable with an array of bioactives—including cytokine-complexing glycosaminoglycans, cell-adhesion-mediating peptides and antimicrobials—APs can be applied to customize materials for demanding biotechnologies in uniquely versatile, simple, and robust ways. Moreover, homo- and heterodisplacement of adsorbed APs provide unprecedented means of in situ alteration and renewal of the functionalized surfaces. The related options are exemplified with proof-of-concept experiments of controlled bacterial adhesion, human umbilical vein endothelial cell, and induced pluripotent cell growth on AP-functionalized surfaces.

中文翻译：

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用于多功能、简便和原位可调表面生物功能化的两亲共聚物

精密表面工程是先进生物材料的关键。报道了一种用于吸附表面生物功能化的聚乙二醇化苯乙烯-马来酸共聚物的新平台。平衡的两亲性使共聚物具有水溶性，但对表面具有很强的亲和性。对其分子结构的微调可以控制对特定材料的吸附锚定——这就是为什么它们被称为“锚定聚合物”（APs）——以及对吸附层的结构特征的控制。可与一系列生物活性物质（包括复合细胞因子的糖胺聚糖、介导细胞粘附的肽和抗菌剂）偶联，AP 可用于以独特的通用、简单和稳健的方式定制材料，以满足要求苛刻的生物技术。而且，吸附的 AP 的同位和异位置换为功能化表面的原位改变和更新提供了前所未有的手段。相关选项以受控细菌粘附、人脐静脉内皮细胞和在 AP 功能化表面上诱导多能细胞生长的概念验证实验为例。