Background

Gait and balance abnormalities are a significant source of morbidity and mortality in progressive supranuclear palsy (PSP). Gait impairment in PSP is primarily assessed clinically on exam or with the use of rating scales. Three dimensional video based gait and balance analysis performed in a laboratory setting is a highly accurate method of motion analysis (Wren et al., 2020), however limited data is available in patients with PSP.

Research question

In this study we assess the objective features of postural control, kinematics, kinetic and temporal-spatial gait metrics in PSP, using three-dimensional video motion analysis in a laboratory setting compared to normal controls.

Methods

Three-dimensional motion was captured using a 10-camera motion capture system, 41 body markers and ground embedded force plates in 16 patients with PSP patients and compared to motorically normal controls.

Results

Spatiotemporal, kinematic, and kinetic gait measures effectively differentiated patients with PSP from controls. Patients had slower gait velocity, lower cadence, increased double support time and abnormal antero-posterior sway. Joint kinematics and kinetics were reduced and showed less variation among patients with PSP compared to controls which is suggestive of bradykinesia. Objective gait measures of abnormality correlated with clinical disease severity. Postural sway metrics distinguished PSP from controls and captured gait imbalance.

Significance

Objective measures of gait and balance abnormalities in patients with PSP provide an outcome measure that can be potentially used for early disease detection, in clinical trials and to validate portable motion capture devices in the future.

中文翻译：

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进行性核上性麻痹患者步态和平衡障碍的实验室评估

背景

步态和平衡异常是进行性核上性麻痹 (PSP) 发病率和死亡率的重要来源。PSP 中的步态障碍主要在临床上通过考试或使用评分量表进行评估。在实验室环境中进行的基于三维视频的步态和平衡分析是一种高度准确的运动分析方法（Wren 等人，2020 年），但在 PSP 患者中可获得的数据有限。

研究问题

在这项研究中，我们在实验室环境中使用三维视频运动分析与正常对照相比，评估 PSP 中姿势控制、运动学、动力学和时空步态指标的客观特征。

方法

使用 10 摄像头运动捕捉系统、41 个身体标记和地面嵌入式测力板在 16 名 PSP 患者中捕捉到三维运动，并与运动正常对照组进行比较。

结果

时空、运动学和动力学步态测量有效地区分 PSP 患者与对照组。患者有较慢的步态速度、较低的节奏、增加的双支撑时间和异常的前后摇摆。与提示运动迟缓的对照组相比，PSP 患者的关节运动学和动力学降低并且显示出较少的变化。异常的客观步态测量与临床疾病严重程度相关。姿势摇摆指标将 PSP 与控制区分开来，并捕获步态不平衡。

意义

PSP 患者步态和平衡异常的客观测量提供了一种结果测量方法，可用于早期疾病检测、临床试验和未来验证便携式运动捕捉设备。