Pentylenetetrazole (PTZ)-induced seizure is one of the gold standard mouse models for rapid evaluation of novel anticonvulsants. Synchronically, PTZ induced kindling in mice is also a simple and well accepted model of chronic epilepsy. PTZ kindling has been explored for studying epileptogenesis, epilepsy-associated comorbidities, and refractory epilepsy. This review summarizes the potential of PTZ kindling in mice and its modifications for its face, construct, and predictive validity to screen antiepileptogenic drugs, combined or add on novel and safe therapies for treatment of epilepsy-associated depression and cognitive impairment as well as effective interventions for pharmacoresistant epilepsy.

戊四唑 (PTZ) 诱导的癫痫发作是快速评估新型抗惊厥药的金标准小鼠模型之一。同时，PTZ 诱导的小鼠点燃也是一种简单且广为接受的慢性癫痫模型。PTZ kindling 已被探索用于研究癫痫发生、癫痫相关合并症和难治性癫痫。这篇综述总结了 PTZ 点燃在小鼠身上的潜力及其对筛选抗癫痫药物的外观、结构和预测有效性的修改，结合或添加新的和安全的治疗癫痫相关抑郁症和认知障碍的疗法以及有效的干预措施用于抗药性癫痫。