The study is aimed at investigating the association of serum irisin、Neuregulin 4 (NRG4), and Anti-müllerian hormone (AMH) with adolescent obesity with Polycystic ovary syndrome (PCOS) and the efficacy of weight management interventions. Serum levels of irisin, NRG4, AMH, sex steroid hormone, body mass index (BMI), serum insulin, and C-peptide were measured in 52 obese adolescent girls with PCOS (PCOS group) and 43 obese adolescent girls without PCOS (non-PCOS group). The levels of AMH, NRG4, serum irisin, sex steroid hormones, BMI, serum insulin, and C-peptide were evaluated in obese PCOS girls before and after one year weight management. The levels of AMH, serum insulin, NRG4, and total testosterone of PCOS group were significantly higher than those of non-PCOS group. On the contrary, serum irisin and serum C-peptide in PCOS group was significantly lower than that in non-PCOS group. The levels of fat mass, percent body fat, total testosterone, AMH, NRG4, and serum insulin in the obese girls with PCOS showed significant decreases compared with before weight management intervention. On the contrary, after one year of body weight management intervention, serum irisin and serum C-peptide was significantly increased. Adolescent obesity complicated with PCOS is significantly associated with glucose and lipid metabolism and sex steroid hormone disorders, but the exact pathophysiological and clinical features are highly variable. Weight management intervention can significantly improve the clinical symptoms and hematological indicators, serum irisin and NRG4 can be used as two essential biomarkers for evaluating weight management.

中文翻译：

---

血清鸢尾素、神经调节蛋白 4 和体重管理对患有多囊卵巢综合征的肥胖少女的影响。

本研究旨在探讨血清鸢尾素、神经调节蛋白 4 (NRG4) 和抗苗勒管激素 (AMH) 与青少年肥胖多囊卵巢综合征 (PCOS) 的关系以及体重管理干预措施的效果。在 52 名患有 PCOS 的肥胖少女（PCOS 组）和 43 名没有 PCOS 的肥胖少女（非PCOS 组）。在体重管理一年前后，对肥胖 PCOS 女孩的 AMH、NRG4、血清鸢尾素、性类固醇激素、BMI、血清胰岛素和 C 肽水平进行了评估。PCOS组AMH、血清胰岛素、NRG4、总睾酮水平显着高于非PCOS组。相反，PCOS组血清鸢尾素和血清C肽明显低于非PCOS组。与体重管理干预前相比，患有 PCOS 的肥胖女孩的脂肪量、体脂百分比、总睾酮、AMH、NRG4 和血清胰岛素水平显着下降。相反，经过一年的体重管理干预，血清鸢尾素和血清C肽显着升高。青少年肥胖并发 PCOS 与糖脂代谢和性类固醇激素紊乱显着相关，但确切的病理生理和临床特征差异很大。体重管理干预可显着改善临床症状和血液学指标，血清鸢尾素和NRG4可作为评价体重管理的两个重要生物标志物。