Chronic inflammation is a major factor in tumor growth and progression. Cancer cells secrete C-X-C chemokine ligand 8 (CXCL8) along with its receptor C-X-C chemokine receptor 1 (CXCR1) and chemokine receptor 2 (CXCR2). It plays a significant role in the activation and trafficking of inflammatory mediators, tumor proliferation and interferes in breast cancer development by controlling cell adhesion, proliferation, migration, and metastasis. This axis also plays a significant role in driving different cancers and melanomas, including breast cancer progression, by controlling stem cell masses. Few small-molecule CXCR1/2 inhibitors and CXCL8 releasing inhibitors have been identified in the past two decades that bind these receptors in their inactive forms and blocks their signaling as well as the biological activities associated with inflammation. Inhibitors of certain inflammatory molecules are projected to be more efficient in different inflammatory diseases. Preclinical trials indicate that patients may be benefitted from combined treatment with targeted drugs, chemotherapies, and immunotherapies. Thus, targeting the CXCL8-CXCR1/2 signaling axis in breast cancer could be a promising approach for its therapeutics. This review examines the roles of the CXCL8-CXCR1/2 signaling axis and how it is implicated in the tumor microenvironment in breast cancer. In addition, we also discuss the potential role of the CXCL8-CXCR1/2 axis in targeted therapeutics for breast cancer.

慢性炎症是肿瘤生长和进展的主要因素。癌细胞分泌 CXC 趋化因子配体 8 (CXCL8) 及其受体 CXC 趋化因子受体 1 (CXCR1) 和趋化因子受体 2 (CXCR2)。它在炎症介质的激活和运输、肿瘤增殖中起重要作用，并通过控制细胞粘附、增殖、迁移和转移来干扰乳腺癌的发展。该轴还通过控制干细胞团在驱动不同的癌症和黑色素瘤（包括乳腺癌的进展）中发挥重要作用。在过去的二十年中，很少有小分子 CXCR1/2 抑制剂和 CXCL8 释放抑制剂以非活性形式结合这些受体并阻断它们的信号传导以及与炎症相关的生物活性。某些炎症分子的抑制剂预计在不同的炎症疾病中更有效。临床前试验表明，患者可能受益于靶向药物、化学疗法和免疫疗法的联合治疗。因此，靶向乳腺癌中的 CXCL8-CXCR1/2 信号轴可能是一种有前途的治疗方法。本综述探讨了 CXCL8-CXCR1/2 信号轴的作用以及它如何与乳腺癌的肿瘤微环境有关。此外，我们还讨论了 CXCL8-CXCR1/2 轴在乳腺癌靶向治疗中的潜在作用。化学疗法和免疫疗法。因此，靶向乳腺癌中的 CXCL8-CXCR1/2 信号轴可能是一种有前途的治疗方法。本综述探讨了 CXCL8-CXCR1/2 信号轴的作用以及它如何与乳腺癌的肿瘤微环境有关。此外，我们还讨论了 CXCL8-CXCR1/2 轴在乳腺癌靶向治疗中的潜在作用。化学疗法和免疫疗法。因此，靶向乳腺癌中的 CXCL8-CXCR1/2 信号轴可能是一种有前途的治疗方法。本综述探讨了 CXCL8-CXCR1/2 信号轴的作用以及它如何与乳腺癌的肿瘤微环境有关。此外，我们还讨论了 CXCL8-CXCR1/2 轴在乳腺癌靶向治疗中的潜在作用。