Emerging pollutants and priority substances are of growing concern due to their toxicity potential to aquatic organisms and human health. However, few reports on this issue in marine ecosystems in general and, more specifically, on the Colombian Caribbean coast are available. The aim of this study was to detect these compounds in sediments from Cartagena Bay (CB) and in the Grand Marsh of Santa Marta, GMSM (Ramsar site), in order to determine how they related to in vitro cytotoxicity assays on HepG2 cells of sediment extracts. A total of thirty compounds were detected using GC–MS/MS in fifteen stations during both the rainy and the dry seasons. Sediments from CB had a wide range of different toxicants, with polycyclic aromatic hydrocarbons (PAHs) being the most prevalent (12 PAHs, 5.5–881.6 ng/g). Total PCBs ranged from < LOD to 18.6 ng/g, with PCB 138 being the most common detected congener. Residues of p,p′-DDE, Chlorpyrifos and two organophosphate flame retardants, TEHP and ToTP, were found in most sampling locations. The UV filters 4MBC and homosalate were recurrently found in sediments, and the fragrance galaxolide appeared in all cases, with the greatest concentrations found on a touristic beach. In GMSM, with the exception of deltamethrin, all chemicals evaluated had lower average values than in CB. According to sediment quality guidelines, some sites in CB presented values of PAHs higher than the threshold effects level, while in the marsh, none of the stations exceeded it. HepG2 cells exposed to 1% sediment extracts presented reduced cell viability up to 26%. Cytotoxicity displayed a negative correlation with chlorpyrifos concentration. In short, these data suggest the bay and the marsh have specific contamination fingerprints related to anthropogenic interventions. This research highlights the need to further investigate the ecotoxicological implications of detected chemical stressors in these ecosystems.

新兴污染物和优先物质因其对水生生物和人类健康的潜在毒性而受到越来越多的关注。然而，关于这个问题的一般海洋生态系统，更具体地说，哥伦比亚加勒比海岸的报告很少。本研究的目的是检测卡塔赫纳湾 (CB) 和圣玛尔塔大沼泽 (GMSM) 沉积物中的这些化合物（拉姆萨尔遗址），以确定它们与沉积物 HepG2 细胞的体外细胞毒性测定的关系提取物。在雨季和旱季，使用 GC-MS/MS 在 15 个站点中总共检测到 30 种化合物。来自 CB 的沉积物具有多种不同的毒物，其中多环芳烃 (PAH) 最为普遍（12 种 PAH，5.5-881.6 ng/g）。总 PCB 的范围从 < LOD 到 18.6 ng/g，PCB 138 是最常见的检测到的同系物。的残留物p，p'-DDE、毒死蜱和两种有机磷阻燃剂 TEHP 和 ToTP，在大多数采样地点被发现。紫外线过滤剂 4MBC 和 homosalate 在沉积物中反复发现，并且在所有情况下都出现了香味 galaxolide，在旅游海滩上发现的浓度最高。在 GMSM 中，除溴氰菊酯外，所有评估的化学品的平均值均低于 CB。根据沉积物质量指南，CB 中一些站点的 PAHs 值高于阈值效应水平，而在沼泽中，没有一个站点超过它。暴露于 1% 沉积物提取物的 HepG2 细胞的细胞活力降低了 26%。细胞毒性与毒死蜱浓度呈负相关。简而言之，这些数据表明海湾和沼泽具有与人为干预相关的特定污染指纹。这项研究强调了进一步调查这些生态系统中检测到的化学压力源的生态毒理学影响的必要性。