The management of bacterial infections, especially trains of methicillin-resistant Staphylococcus aureus observe in health care settings, has markedly improved with the introduction of established drugs but using newer nano-based formulations. This study investigates the effects of vancomycin-linoleic acid nanoparticles on testicular tissue in an experimental animal model. Twenty-five adult male Sprague-Dawley rats maintained at the Animal House of the Biomedical Resources Unit were assigned to five groups namely E - solid lipid nanoparticles; F - vancomycin solid lipid nanoparticle; G - linoleic acid nanoparticle; H - vancomycin linoleic acid; and A - control. Perturbations in seminal fluid parameters showed a reduced sperm count in groups F & G which was statistically significant (p < .05) but motility and morphology were not significant when compared to controls (A). Reduced testosterone levels were found in groups E, F and H but were not statistically significant (p > .05). There was also increased luteinizing hormone (LH) and decreased in follicular stimulating hormone (FSH) levels was statistically significant (p < .05). Hypoplasia, tubular atrophy and shrinkage were observed in histologic sections of the treated groups with basement membrane thickening. Vancomycin solid lipid nanoparticle and its constituents SLN and LA disrupted testicular morphometry and the hormonal milieu sufficient to potentially induce altered reproductive function.

中文翻译：

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万古霉素亚油酸纳米粒对 Sprague-Dawley 大鼠雄性生殖指数的影响。

细菌感染的管理，尤其是在医疗保健机构中观察到的耐甲氧西林金黄色葡萄球菌，随着已建立的药物的引入但使用更新的纳米制剂得到了显着改善。本研究在实验动物模型中研究万古霉素-亚油酸纳米颗粒对睾丸组织的影响。将 25 只成年雄性 Sprague-Dawley 大鼠饲养在生物医学资源单位的动物房，被分配到五组，即 E - 固体脂质纳米颗粒；F - 万古霉素固体脂质纳米颗粒；G——亚油酸纳米颗粒；H——万古霉素亚油酸；和 A - 控制。精液参数的扰动显示 F 组和 G 组的精子数量减少，这具有统计学意义（p < . 05) 但与对照组 (A) 相比，运动性和形态不显着。在 E、F 和 H 组中发现睾酮水平降低，但无统计学意义 (p > .05)。黄体生成素 (LH) 水平也增加，卵泡刺激素 (FSH) 水平下降具有统计学意义 (p < .05)。治疗组组织切片可见发育不全、肾小管萎缩和收缩，基底膜增厚。万古霉素固体脂质纳米颗粒及其成分 SLN 和 LA 破坏了睾丸形态测量和足以潜在诱导生殖功能改变的激素环境。黄体生成素 (LH) 水平也增加，卵泡刺激素 (FSH) 水平下降具有统计学意义 (p < .05)。治疗组组织切片可见发育不全、肾小管萎缩和收缩，基底膜增厚。万古霉素固体脂质纳米颗粒及其成分 SLN 和 LA 破坏了睾丸形态测量和足以潜在诱导生殖功能改变的激素环境。黄体生成素 (LH) 水平也增加，卵泡刺激素 (FSH) 水平下降具有统计学意义 (p < .05)。治疗组组织切片可见发育不全、肾小管萎缩和收缩，基底膜增厚。万古霉素固体脂质纳米颗粒及其成分 SLN 和 LA 破坏了睾丸形态测量和足以潜在诱导生殖功能改变的激素环境。