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Electrochemical strategies for the detection of cTnI
Analyst ( IF 4.2 ) Pub Date : 2021-08-04 , DOI: 10.1039/d1an00808k
Zhipeng Yuan 1, 2 , Li Wang 1, 2 , Jun Chen 1, 2 , Weiguang Su 1, 2 , Anqing Li 1, 2 , Guosheng Su 1, 2 , Pengbo Liu 1, 2 , Xiangxiang Zhou 3
Affiliation  

Acute myocardial infarction (AMI) is the main cause of death from cardiovascular diseases. Thus, early diagnosis of AMI is essential for the treatment of irreversible damage from myocardial infarction. Traditional electrocardiograms (ECG) cannot meet the specific detection of AMI. Cardiac troponin I (cTnI) is the main biomarker for the diagnosis of myocardial infarction, and the detection of cTnI content has become particularly important. In this review, we introduced and compared the advantages and disadvantages of various cTnI detection methods. We focused on the analysis and comparison of the main indicators and limitations of various cTnI biosensors, including the detection range, detection limit, specificity, repeatability, and stability. In particular, we pay more attention to the application and development of electrochemical biosensors in the diagnosis of cardiovascular diseases based on different biological components. The application of electrochemical microfluidic chips for cTnI was also briefly introduced in this review. Finally, this review also briefly discusses the unresolved challenges of electrochemical detection and the expectations for improvement in the detection of cTnI biosensing in the future.

中文翻译:

检测 cTnI 的电化学策略

急性心肌梗死(AMI)是心血管疾病死亡的主要原因。因此,AMI 的早期诊断对于治疗心肌梗塞造成的不可逆损伤至关重要。传统的心电图(ECG)无法满足AMI的特异性检测。心肌肌钙蛋白I(cTnI)是诊断心肌梗死的主要生物标志物,检测cTnI含量变得尤为重要。在这篇综述中,我们介绍并比较了各种 cTnI 检测方法的优缺点。我们重点分析和比较了各种cTnI生物传感器的主要指标和局限性,包括检测范围、检测限、特异性、重复性和稳定性。特别是,我们更加关注基于不同生物成分的电化学生物传感器在心血管疾病诊断中的应用和发展。本综述还简要介绍了电化学微流控芯片在 cTnI 中的应用。最后,这篇综述还简要讨论了电化学检测尚未解决的挑战以及对未来 cTnI 生物传感检测改进的期望。
更新日期:2021-08-24
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