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MPA-Free Generation of Trialkylsilyllithium Reagents and Its Applications to the Synthesis of Silylboronic Esters
Synthesis ( IF 2.6 ) Pub Date : 2021-07-26 , DOI: 10.1055/a-1558-9135
Martin Oestreich 1 , Hiroto Yoshida 2 , Shintaro Kamio 1, 2 , Taiki Imagawa 2 , Masaaki Nakamoto 2
Affiliation  

Trialkylsilyllithium species have turned out to be facilely generated by treating hexaalkyldisilanes with methyllithium in the presence of tris(N,N-tetramethylene)phosphoric triamide (TPPA) as an activator, which can be trapped by boron electrophiles to afford silylboronic esters including long-awaited Me3Si–B(pin).

中文翻译:

无 MPA 生成三烷基甲硅烷基锂试剂及其在合成甲硅烷基硼酸酯中的应用

在三(N,N-四亚甲基)磷三酰胺(TPPA)作为活化剂存在的情况下,通过用甲基锂处理六烷基乙硅烷可以很容易地生成三烷基甲硅烷基锂物质,该物质可以被硼亲电试剂捕获,得到包括期待已久的甲硅烷基硼酸酯。 Me3Si–B(引脚)。
更新日期:2021-08-24
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