A novel carbon based catalyst has been prepared for the synthesis of potential anticancer compounds with low toxicity by an ionic liquid assisted doping process. Sulphonic acid functionalized nitrogen sulphur co-doped graphite (SO₃H-NSG) based catalyst was prepared by coating the carbon surface with the sulphonic acid bearing ionic liquid and annealing the resulting compound. X-ray photoelectron spectroscopy revealed the successful doping of nitrogen and sulphur atoms in the graphitic matrix and the functionalization of the surface with sulphonic acidic sites. The catalyst was used for the synthesis of biologically active coumarin-substituted bis(indolyl)methanes that were finally evaluated for their toxicity and anticancer properties. The cytotoxicity results unveiled that the iodo derivative of the coumarin-substituted bis(indolyl)methanes showed best anti-cancer activity among the four derivatives synthesized.

已经制备了一种新型碳基催化剂，用于通过离子液体辅助掺杂过程合成潜在的低毒性抗癌化合物。磺酸功能化氮硫共掺杂石墨（SO ₃H-NSG) 基催化剂是通过用带有磺酸的离子液体涂覆碳表面并将所得化合物退火来制备的。X 射线光电子能谱揭示了石墨基体中氮和硫原子的成功掺杂以及表面具有磺酸位点的功能化。该催化剂用于合成具有生物活性的香豆素取代的双（吲哚基）甲烷，最终对其毒性和抗癌特性进行了评估。细胞毒性结果表明，香豆素取代的双（吲哚基）甲烷的碘衍生物在合成的四种衍生物中表现出最好的抗癌活性。