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An ON-OFF Magneto-Optical Probe of Anisotropic Biofluid Crystals: A β-Hematin Case Study
IEEE Transactions on Magnetics ( IF 2.1 ) Pub Date : 2021-07-09 , DOI: 10.1109/tmag.2021.3096046
Danielle Kara 1 , Robert J Deissler 2 , Rose Al Helo 2 , Kyle Blasinsky 1 , Brian T Grimberg 3 , Robert Brown 2
Affiliation  

We have designed, developed, and evaluated an innovative portable magneto-optical detector (MOD) in which a light beam with variable polarization passes through a fluid sample immersed in a variable magnetic field. The light intensity is measured downstream along the forward scattering direction. The field is turned on and off through the in-and-out motion of nearby permanent magnets. As a result, for sufficiently, magnetically, and optically anisotropic samples, the optical absorption is sensitive to changes in the light polarization. Both detection and characterization applications are, therefore, available. For instance, both the degree of malaria infection and hemozoin crystalline properties can be measured and studied, respectively. We present experimental results for synthetic hemozoin and describe them in terms of the basic physics and chemistry underlying the correlations of the directions of the external magnetic field and the light beam polarization. We connect this work to a commercialized product for malaria detection and compare it with other magneto-optical instruments and methods. We conduct tests of absorption parameters and the electric polarizability tensor, and we discuss the connection to magnetic and electric dipole moments.

中文翻译:

各向异性生物流体晶体的开关磁光探针:β-血红素案例研究

我们设计、开发和评估了一种创新的便携式磁光检测器 (MOD),其中具有可变偏振的光束穿过浸入可变磁场中的流体样品。沿着前向散射方向在下游测量光强度。通过附近永磁体的进出运动来打开和关闭磁场。因此,对于充分、磁性和光学各向异性的样品,光吸收对光偏振的变化很敏感。因此,检测和表征应用程序都是可用的。例如,可以分别测量和研究疟疾感染程度和 hemozoin 结晶特性。我们展示了合成血红素的实验结果,并根据外部磁场方向和光束偏振方向相关性的基础物理和化学来描述它们。我们将这项工作与用于疟疾检测的商业化产品联系起来,并将其与其他磁光仪器和方法进行比较。我们对吸收参数和电极化张量进行了测试,并讨论了与磁偶极矩和电偶极矩的关系。
更新日期:2021-08-24
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