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Changes in Circulating Kisspeptin Levels During Each Trimester in Women With Antenatal Complications
The Journal of Clinical Endocrinology & Metabolism ( IF 5.8 ) Pub Date : 2021-08-24 , DOI: 10.1210/clinem/dgab617
Ali Abbara 1 , Maya Al-Memar 2 , Maria Phylactou 1 , Elisabeth Daniels 1 , Bijal Patel 1 , Pei C Eng 1 , Rans Nadir 1 , Chioma Izzi-Engbeaya 1 , Sophie A Clarke 1 , Edouard G Mills 1 , Tia Hunjan 1 , Ewa Pacuszka 1 , Lisa Yang 1 , Paul Bech 1 , Tricia Tan 1 , Alexander N Comninos 1 , Tom W Kelsey 3 , Christopher Kyriacou 2 , Hanine Fourie 2 , Tom Bourne 2, 4 , Waljit S Dhillo 1
Affiliation  

Abstract
Context
Antenatal complications such as hypertensive disorders of pregnancy (HDP), fetal growth restriction (FGR), gestational diabetes (GDM), and preterm birth (PTB) are associated with placental dysfunction. Kisspeptin has emerged as a putative marker of placental function, but limited data exist describing circulating kisspeptin levels across all 3 trimesters in women with antenatal complications.
Objective
We aimed to assess whether kisspeptin levels are altered in women with antenatal complications.
Methods
Women with antenatal complications (n = 105) and those with uncomplicated pregnancies (n = 265) underwent serial ultrasound scans and blood sampling at the Early Pregnancy Assessment Unit at Hammersmith Hospital, UK, at least once during each trimester (March 2014 to March 2017). The women with antenatal complications (HDP [n = 32], FGR [n = 17], GDM [n = 35], PTB [n = 11], and multiple complications [n=10]) provided 373 blood samples and the controls provided 930 samples. Differences in circulating kisspeptin levels were assessed.
Results
Third-trimester kisspeptin levels were higher than controls in HDP but lower in FGR. The odds of HDP adjusted for gestational age, maternal age, ethnicity, BMI, smoking, and parity were increased by 30% (95% CI, 16%-47%; P < 0.0001), and of FGR were reduced by 28% (95% CI, 4-46%; P = 0.025), for every 1 nmol/L increase in plasma kisspeptin. Multiple of gestation-specific median values of kisspeptin were higher in pregnancies affected by PTB (P = 0.014) and lower in those with GDM (P = 0.020), but not significantly on multivariable analysis.
Conclusion
We delineate changes in circulating kisspeptin levels at different trimesters and evaluate the potential of kisspeptin as a biomarker for antenatal complications.


中文翻译:

有产前并发症的女性在每个孕期循环 Kisspeptin 水平的变化

摘要
语境
妊娠期高血压疾病 (HDP)、胎儿生长受限 (FGR)、妊娠糖尿病 (GDM) 和早产 (PTB) 等产前并发症与胎盘功能障碍有关。Kisspeptin 已成为胎盘功能的推定标志物,但描述产前并发症女性所有 3 个三个月的循环 Kisspeptin 水平的数据有限。
客观的
我们的目的是评估产前并发症女性的 Kisspeptin 水平是否发生变化。
方法
有产前并发症的妇女 (n = 105) 和无并发症妊娠的妇女 (n = 265) 在每个孕期(2014 年 3 月至 2017 年 3 月)至少在英国哈默史密斯医院的早期妊娠评估部门接受系列超声扫描和血液采样)。有产前并发症的妇女(HDP [n = 32]、FGR [n = 17]、GDM [n = 35]、PTB [n = 11] 和多种并发症 [n = 10])提供了 373 份血液样本和对照组提供了 930 个样品。评估了循环kisspeptin水平的差异。
结果
在 HDP 中,孕晚期 Kisspeptin 水平高于对照组,但在 FGR 中较低。调整胎龄、产妇年龄、种族、BMI、吸烟和产次的 HDP 几率增加了 30%(95% CI,16%-47%;P  < 0.0001),FGR 降低了 28%( 95% CI, 4-46%;P  = 0.025),血浆 Kisspeptin 每增加 1 nmol/L。在受 PTB 影响的妊娠中,kisspeptin 的倍数妊娠特异性中值较高(P  = 0.014),在 GDM 影响的妊娠中较低(P  = 0.020),但在多变量分析中不显着。
结论
我们描绘了不同孕期循环中kisspeptin 水平的变化,并评估了kisspeptin 作为产前并发症生物标志物的潜力。
更新日期:2021-08-24
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