Abstract

Our previous study has firstly pointed that three nucleotide variants (g.−11C > T, g.117A > G, and g.149C > T) of the goat PRNT gene can significantly influence litter size. Given litter size is positively correlated with growth performance, we consider whether the PRNT gene also acts on the growth performance in goats. In this work, a correlation analysis among different litter size types and growth traits of Shaanbei white cashmere (SBWC) goats was performed, and results showed that a positive correlation did exist in our detected population (P < 0.01). Then, the association among different genotypes of three variations and goat growth performance was measured. Our results pointed to g.117A > G being significantly associated with the cannon circumference (P = 4.60E-05) while no significant effect was found between another two SNPs and growth traits after the Bonferroni’s correction (P*n < 0.05). Together, this is the first report about the influence of the PRNT gene on the growth of goat and g.117A > G can be regarded as a possible DNA marker applying for MAS breeding.

摘要

我们之前的研究首先指出山羊PRNT基因的三个核苷酸变异（g.−11C > T，g.117A > G和g.149C > T）可以显着影响窝产仔数。鉴于窝产仔数与生长性能呈正相关，我们考虑PRNT基因是否也对山羊的生长性能起作用。本文对陕北白绒（SBWC）山羊不同产仔数类型与生长性状进行了相关分析，结果表明在我们检测的种群中确实存在正相关（ P < 0.01 ）  。然后，测量了三种变异的不同基因型与山羊生长性能之间的关联。我们的结果表明 g.117A > G 与大炮周长显着相关（P  = 4.60E-05) 而在 Bonferroni 校正后，另外两个 SNP 与生长性状之间没有发现显着影响 ( P * n  < 0.05)。综上所述，这是首次报道PRNT基因对山羊生长的影响，g.117A>G可作为一种可能应用于MAS育种的DNA标记。