Objectives

The ability to remain in employment addresses an important consequence of stroke beyond the usual clinical parameters. However, data on the association between time to intravenous thrombolysis and workforce attachment in patients with acute ischemic stroke are sparse.

Materials and methods

In this nationwide cohort study, stroke patients of working age (18-60 years) treated with thrombolysis (2011-2016) who were part of the workforce prior to admission and alive at discharge were identified using the Danish Stroke Registry. The association between time to thrombolysis and workforce attachment one year later was examined with multivariable logistic regression.

Results

The study population comprised 1,329 patients (median age 51 years [25^th-75^th percentile 45-56], 67.3% men). The median National Institutes of Health Stroke Scale score at presentation was 4 (25^th-75^th percentile 2-8), and the median time from symptom-onset to initiation of thrombolysis was 140min (25^th-75^th percentile 104-196min). The proportion of patients who were part of the workforce at one-year follow-up was 64.6%, 64.3%, 64.9%, and 60.0% in patients receiving thrombolysis within 90min, between 91-180min, between 181-270min, and after 270min, respectively. In adjusted analysis, time to thrombolysis between 91-180min, 181-270min, and >270min was not significantly associated with workforce attachment compared with thrombolysis received ≤90min of symptom-onset (ORs 0.89 [95%CI 0.60-1.31], 0.93 [0.66-1.31], and 0.80 [0.43-1.52], respectively).

Conclusions

In patients of working age admitted with stroke and treated with thrombolysis, two out of three were part of the workforce one year after discharge. There was no graded relationship between time to thrombolysis and the likelihood of workforce attachment.

中文翻译：

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缺血性中风后的劳动力依恋——溶栓治疗时间的重要性

目标

继续工作的能力解决了中风的一个重要后果，超出了通常的临床参数。然而，关于急性缺血性卒中患者静脉溶栓时间与劳动力依恋之间关系的数据很少。

材料和方法

在这项全国性队列研究中，使用丹麦中风登记处确定了在入院前已加入工作并在出院时存活的接受溶栓治疗（2011-2016 年）的工作年龄（18-60 岁）中风患者。用多变量逻辑回归检查溶栓时间与一年后劳动力依恋之间的关联。

结果

研究人群包括 1,329 名患者（中位年龄 51 岁 [25 ^th -75 ^th百分位 45-56]，67.3% 为男性）。就诊时美国国立卫生研究院卒中量表评分中位数为 4 分（25 ^th -75 ^th百分位数 2-8），从症状发作到溶栓开始的中位时间为 140 分钟（25 ^th -75 ^th百分位 104-196 分钟）。90min内、91-180min内、181-270min内、270min后接受溶栓治疗的患者在1年随访中成为劳动力的比例分别为64.6%、64.3%、64.9%和60.0% ， 分别。在调整后的分析中，91-180 分钟、181-270 分钟和 >270 分钟之间的溶栓时间与工作人员依恋度没有显着相关性，而溶栓时间≤90 分钟（ORs 0.89 [95%CI 0.60-1.31]，0.93 [ 0.66-1.31] 和 0.80 [0.43-1.52]）。

结论

在因中风入院并接受溶栓治疗的工作年龄患者中，三分之二的患者在出院一年后进入劳动力市场。溶栓时间与员工依恋的可能性之间没有分级关系。