Abstract

Background

Ventricular arrhythmias are life-threatening complications of heart failure (HF). Galectin-3, an indicator of fibrosis, is associated with incident HF and was found to be related to poor prognosis in these patients. We aimed to investigate the association of galectin-3 level with left ventricular (LV) arrhythmias in HF.

Methods

A total of 92 non-ischaemic HF patients who had implantable cardioverter-defibrillator were included in this study. Patients were divided into two groups based on the galectin-3 level. Ventricular arrhythmic events and LV strain indices were compared between the two groups. Negative binomial regression was used to detect the independent predictors of total arrhythmic events in HF patients.

Results

The median age was 65 (54–71) in the high galectin-3 group (HGAL) and 62 (52–68) in the low galectin-3 group (LGAL). Ventricular arrhythmic events were more frequent in HGAL than in LGAL, including non-sustained ventricular tachycardia (VTnon), sustained-VT (VTs), and ventricular fibrillation (VF) (p < 0.0001, p = 0.002, and p = 0.026, respectively). There were no statistically significant differences between HGAL and LGAL in terms of LV strain measurements. Galectin-3 level was positively significantly correlated with total arrhythmic events (r = 0.58, p < 0.001), but no correlation was found between galectin-3 and LV global longitudinal strain (r = 0.15, p = 0.16). Galectin-3 was an independent predictor of total ventricular arrhythmic events in HF patients (p < 0.0001).

Conclusion

VTnon, VTs, and VF events were higher in HGAL compared to LGAL. Galectin-3 was an independent predictor of total ventricular arrhythmic events in HF patients and might be used to detect high-risk HF patients for arrhythmic events.

中文翻译：

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植入式心律转复除颤器心力衰竭患者半乳糖凝集素3水平与室性心律失常和左心室劳损的相关性

摘要

背景

室性心律失常是心力衰竭 (HF) 的危及生命的并发症。Galectin-3 是纤维化的指标，与心衰事件有关，并被发现与这些患者的不良预后有关。我们旨在研究半乳糖凝集素 3 水平与 HF 左心室 (LV) 心律失常的关系。

方法

本研究共纳入了 92 名植入式心律转复除颤器的非缺血性 HF 患者。根据半乳糖凝集素 3 水平将患者分为两组。比较两组间的室性心律失常事件和 LV 应变指数。负二项式回归用于检测 HF 患者总心律失常事件的独立预测因子。

结果

高半乳糖凝集素 3 组 (HGAL) 的中位年龄为 65 (54–71)，低半乳糖凝集素 3 组 (LGAL) 的中位年龄为 62 (52–68)。HGAL 中的室性心律失常事件比 LGAL 中更频繁，包括非持续性室性心动过速 (VTnon)、持续性 VT (VTs) 和心室颤动 (VF)（分别为p  < 0.0001、p  = 0.002 和p  = 0.026 ). 在 LV 应变测量方面，HGAL 和 LGAL 之间没有统计学上的显着差异。Galectin-3 水平与总体心律失常事件显着正相关 ( r  = 0.58, p  < 0.001)，但在 galectin-3 和 LV 整体纵向应变之间未发现相关性 ( r  = 0.15, p = 0.16）。Galectin-3 是 HF 患者总室性心律失常事件的独立预测因子 ( p  < 0.0001)。

结论

与 LGAL 相比，HGAL 中的 VTnon、VT 和 VF 事件更高。Galectin-3 是 HF 患者总室性心律失常事件的独立预测因子，可用于检测高危 HF 患者的心律失常事件。