当前位置: X-MOL 学术World J. Surg. Onc. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
miR-499a inhibits the proliferation and apoptosis of prostate cancer via targeting UBE2V2
World Journal of Surgical Oncology ( IF 3.2 ) Pub Date : 2021-08-24 , DOI: 10.1186/s12957-021-02371-7
Yougan Chen 1 , Fanghao Sun 1 , Liansheng Zhang 1 , Jian Zhou 1 , Jianquan Hou 1
Affiliation  

Prostate cancer is one of the malignant tumors of the urinary system and ranks second among the fatal cancers in men. And with age, the incidence of prostate cancer will increase linearly. In this study, we measured the expression of Ubiquitin Conjugating Enzyme E2 V2 (UBE2V2) in prostate cancer tissues and cell lines by WB and explored the effect of UBE2V2 on the proliferation characteristics of prostate cancer by MTT and colony formation test. In our research, we found that the UBE2V2 protein level in prostate cancer cell lines was significantly higher than the UBE2V2 protein level in normal prostate cells, and the mRNA expression level did not change significantly compared with normal prostate tissue cells. At the same time, we found that miR-499a combined with UBE2V2 inhibited the expression of UBE2V2 in prostate cancer cells. In conclusion, our results indicate that miR-499a inhibits the proliferation of human prostate cancer cells by targeting UBE2V2, which will provide a potential target for the treatment of prostate cancer.

中文翻译:

miR-499a通过靶向UBE2V2抑制前列腺癌的增殖和凋亡

前列腺癌是泌尿系统恶性肿瘤之一,在男性致死性癌症中居第二位。而且随着年龄的增长,前列腺癌的发病率会线性增加。本研究采用WB检测泛素结合酶E2 V2(UBE2V2)在前列腺癌组织和细胞系中的表达,并通过MTT和集落形成试验探讨UBE2V2对前列腺癌增殖特性的影响。在我们的研究中,我们发现前列腺癌细胞系中UBE2V2蛋白水平明显高于正常前列腺细胞中UBE2V2蛋白水平,与正常前列腺组织细胞相比,mRNA表达水平没有明显变化。同时我们发现miR-499a联合UBE2V2抑制前列腺癌细胞中UBE2V2的表达。综上所述,
更新日期:2021-08-24
down
wechat
bug