Abstract

The biological aggressiveness of a tumor is determined by the ability of tumor cells to invade and metastasize which is a consequence of their acquisition of a number of phenotypic characteristics. Remodeling of the actin cytoskeleton occurs during cell migration which is carried out by various groups of actin binding proteins in the regulation of which proteasomes and calpains play an important role. Therefore the study of the relationship of proteins associated with cell motility with the processes of lymphogenous metastasis as well as the assessment of the regulatory role of intracellular proteases in these processes is extremely important for fundamental oncology. This study demonstrates the associations of actin-binding proteins with the activity of proteasomes and calpain, which are specific for tumors and metastases of the mammary gland. We proposed a possible scheme of the relationship of intracellular systems with the actin-binding proteins. The results obtained expand the fundamental understanding of the processes of tumor progression and can also be used in the search for proteins-targets for therapeutic action in molecular targeted cancer therapy.

中文翻译：

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细胞迁移蛋白水平与乳腺癌蛋白水解和淋巴转移过程的关系估计

摘要

肿瘤的生物学侵袭性由肿瘤细胞侵入和转移的能力决定，这是它们获得许多表型特征的结果。肌动蛋白细胞骨架的重塑发生在细胞迁移过程中，这是由不同组的肌动蛋白结合蛋白进行的，蛋白酶体和钙蛋白酶在其中发挥重要作用。因此，研究与细胞运动相关的蛋白质与淋巴转移过程的关系以及评估细胞内蛋白酶在这些过程中的调节作用对于基础肿瘤学极为重要。这项研究证明了肌动蛋白结合蛋白与蛋白酶体和钙蛋白酶活性的关联，这些蛋白酶体和钙蛋白酶对乳腺的肿瘤和转移灶具有特异性。我们提出了细胞内系统与肌动蛋白结合蛋白之间关系的可能方案。获得的结果扩展了对肿瘤进展过程的基本理解，也可用于寻找在分子靶向癌症治疗中发挥治疗作用的蛋白质靶点。