Recently, smart hydrogels have attracted much attention for their abilities to respond to subtle changes in external and internal stimuli. Also, natural polysaccharide-based biomaterials are more appealing for their biocompatibility and biodegradability. However, limitations owing to their complex compositions and mechanisms, cumbersome synthetic routes, and single function call for a simple and effective strategy to develop novel multifunctional smart hydrogels. Herein, this developed work was achieved based on Bletilla striata polysaccharide (BSP), a kind of natural glucomannan with diverse bioactivities and biocompatibility, we fabricated a low-cost multifunctional hydrogel by oxidizing the catechol groups of carboxymethylated BSP(CBSP)-dopamine(DA) conjugate with adhesion, antioxidant, and pH-responsive properties. In this hydrogel system, CBSP as the backbone material, was negatively charged and conferred the hydrogel with pH sensitivity. The presence of catechol groups greatly enhanced the tissue adhesion and antioxidant capacities of the hydrogel. Meanwhile, the highly porous structure of hydrogel allowed berberine to be encapsulated and released to exhibit excellent and long-lasting antibacterial activity. In summary, the adhesion, antioxidant, pH-sensitive, and antibacterial multifunctional hydrogel showed massive potential in the biomedical field.

最近，智能水凝胶因其对外部和内部刺激的细微变化做出反应的能力而备受关注。此外，基于天然多糖的生物材料因其生物相容性和生物降解性而更具吸引力。然而，由于其复杂的组成和机制、繁琐的合成路线和单一功能的局限性，需要一种简单有效的策略来开发新型多功能智能水凝胶。在此，这项开发工作是基于Bletilla striata实现的多糖 (BSP) 是一种具有多种生物活性和生物相容性的天然葡甘露聚糖，我们通过氧化羧甲基化 BSP(CBSP)-多巴胺 (DA) 偶联物​​的儿茶酚基团，具有粘附性、抗氧化性和 pH 响应性，制备了低成本的多功能水凝胶特性。在这个水凝胶系统中，CBSP 作为骨架材料，带负电荷并赋予水凝胶 pH 敏感性。儿茶酚基团的存在大大增强了水凝胶的组织粘附和抗氧化能力。同时，水凝胶的高度多孔结构允许小檗碱被包裹和释放，从而表现出优异且持久的抗菌活性。总之，粘附、抗氧化、pH敏感和抗菌的多功能水凝胶在生物医学领域显示出巨大的潜力。