Mob1/phocein family proteins are conserved from yeast to mammals. Human has four MOB genes, MOB1, 2, 3 and 4. Human MOB1 protein, which is a component of the Hippo pathway, is involved in the inhibition of yes-associated protein (YAP1) through large tumor suppressor (LATS) kinases and plays a tumor suppressive role. In contrast, MOB4 activates YAP1. Caernorhabditis elegans (C. elegans) also has four MOB genes. Moreover, C. elegans has homologues of YAP1 (Ce_YAP-1) and LATS kinases (WTS-1). Nevertheless, our previous study revealed that the Hippo pathway is not conserved in C. elegans and that heat shock activates Ce_YAP-1. We also reported that Ce_YAP-1 is involved in the regulation of life span, healthy lifespan and thermotolerance. In this study, we raised a question whether and how C. elegans homologue of MOB4 (Ce_MOB-4) is involved in the regulation of Ce_YAP-1. Ce_MOB-4 is ubiquitously expressed in adult worms. This expression pattern is similar to that of Ce_YAP-1. mob-4 loss-of-function mutants show short life span, short health life span and compromise thermotolerance. However, heat shock activates Ce_YAP-1 in mob-4 mutant. In conclusion, the role of MOB4 in the activation of YAP1 is not conserved in C. elegans.

中文翻译：

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失去秀丽隐杆线虫与人类 MOB4 的同源物会影响寿命、健康寿命和耐热性

Mob1/phocein 家族蛋白从酵母到哺乳动物都是保守的。人类有四个MOB基因，MOB1、2、3和4。_ 人类 MOB1 蛋白是 Hippo 通路的一个组成部分，通过大肿瘤抑制因子 (LATS) 激酶参与抑制相关蛋白 (YAP1) 并发挥肿瘤抑制作用。相反，MOB4 激活 YAP1。秀丽隐杆线虫( C. elegans ) 也有四个MOB基因。此外，C . 线虫具有 YAP1 (Ce_YAP-1) 和 LATS 激酶 (WTS-1) 的同源物。然而，我们之前的研究表明，Hippo 途径在C中并不保守。线虫和热休克激活 Ce_YAP-1。我们还报道了 Ce_YAP-1 参与调节寿命、健康寿命和耐热性。在这项研究中，我们提出了一个问题C是否以及如何。MOB4 (Ce_MOB-4) 的线虫同系物参与了 Ce_YAP-1 的调节。Ce_MOB-4 在成虫中普遍表达。这种表达模式类似于 Ce_YAP-1。mob-4功能丧失突变体显示寿命短、健康寿命短和耐热性受损。然而，热激激活 Ce_YAP-1 在mob-4突变体。总之，MOB4 在激活 YAP1 中的作用在C中是不保守的。线虫_