Gene mutation detection and identification are conducive for detection of disease. He, Sunil and team report the electronic characteristics of the gene of breast cancer 1 in four common mutation types: duplication, single nucleotide variation, deletion and indel. The HOMO (left) and HOMO-1 (right) distribution for TCACAAGCA (above) and TCACXAGCA (below) explain the largest decrease in conductance upon deletion of an AT base pair. Each mutation shows a distinct change in conductance which can be used to identify the mutation. The results open up a new possibility for designing an efficient and low-cost sensor for electronically detecting DNA mutations. (DOI: 10.1002/bip.23465)

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基因突变检测和鉴定有利于疾病的检测。他、Sunil 和团队报告了四种常见突变类型中乳腺癌 1 基因的电子特征：重复、单核苷酸变异、缺失和插入缺失。TCACAAGCA（上图）和 TCACXAGCA（下图）的 HOMO（左）和 HOMO-1（右）分布解释了删除 AT 碱基对后电导的最大下降。每个突变都显示出电导的明显变化，可用于识别突变。结果为设计用于电子检测 DNA 突变的高效低成本传感器开辟了新的可能性。（DOI：10.1002/bip.23465）