Depression is a common mental illness that belongs to the category of emotional disorders that causes serious damage to the health and life of patients, while inflammation is considered to be one of the important factors that cause depression. In this case, it might be important to explore the possible therapeutic approach by using natural compounds exerting an anti-inflammatory and antidepressant effect, which has not been systematically reviewed recently. Hence, this review aims to systematically sort the literature related to the mechanism of exerting an antidepressant effect through antiinflammatory actions and to summarize the related natural products in the past 20 years in terms of several inflammatory-related pathways (i.e., the protein kinase B (Akt) pathway, monoamine neurotransmitters (5-hydroxytryptamine and norepinephrine) (5-HT and NE), the nod-like receptor protein-3 (NLRP3) inflammasome, proinflammatory cytokines, neurotrophins, or cytokine-signaling pathways), which might provide a useful reference for the potential treatment of depression.

中文翻译：

---

天然化合物通过抗炎发挥抗抑郁作用的研究进展。

抑郁症是一种常见的精神疾病，属于情绪障碍的范畴，对患者的健康和生活造成严重损害，而炎症被认为是导致抑郁症的重要因素之一。在这种情况下，通过使用具有抗炎和抗抑郁作用的天然化合物来探索可能的治疗方法可能很重要，但最近尚未对其进行系统评价。因此，本综述旨在系统梳理有关通过抗炎作用发挥抗抑郁作用机制的文献，并从几个炎症相关途径（即蛋白激酶B（ Akt) 途径，