Injectable bioelectronic devices provide programmable drug volume delivery control via flexible electrochemical pumps featuring scalable designs for localized drug delivery experiments involving small animals and future drug delivery in humans, especially for life saving medication. A model for the drug delivery time is established from the ideal gas law, finite-deformation theory of flexible membrane, and microfluidics of the channel. It identifies two non-dimensional parameters involving the electrochemical, flexural, and microfluidic terms to control the drug delivery process. An analytical solution is derived from the perturbation method, which agrees well with the numerical solution. These results have relevance in design/optimization of bioelectronic devices used in localized delivery studies in small animals and humans where drug delivery time is an important parameter to ensure complete delivery within a required timeframe.

可注射生物电子设备通过灵活的电化学泵提供可编程的药物体积输送控制，该泵具有可扩展的设计，用于涉及小动物的局部药物输送实验和未来的人类药物输送，尤其是救生药物。从理想气体定律、柔性膜的有限变形理论和通道的微流体学建立了药物递送时间模型。它确定了涉及电化学、弯曲和微流体术语的两个无量纲参数，以控制药物输送过程。由扰动法推导出解析解，与数值解非常吻合。