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Prepulse inhibition can predict the motivational effects of cocaine in female mice exposed to maternal separation
Behavioural Brain Research ( IF 2.7 ) Pub Date : 2021-08-23 , DOI: 10.1016/j.bbr.2021.113545
M Carmen Arenas 1 , Adriana Castro-Zavala 2 , Ana Martín-Sánchez 3 , María Carmen Blanco-Gandía 4 , José Miñarro 1 , Olga Valverde 5 , Carmen Manzanedo 1
Affiliation  

The prepulse inhibition (PPI) of the startle response can identify the rodents that are more sensitive to the effects of cocaine. Mice with a lower PPI presented a higher vulnerability to the effects of cocaine and a higher susceptibility to developing a substance use disorder (SUD). Maternal separation with early weaning (MSEW) is a relevant animal model to induce motivational alterations throughout life. Nevertheless, only a few studies on females exist, even though they are more vulnerable to stress- and cocaine-related problems. Hence, the aim of the present study was to evaluate the ability of PPI to identify females with a greater vulnerability to the long-term consequences of early stress on the motivational effects of cocaine. Female mice underwent MSEW and were classified according to their high or low PPI. They were then assessed in the cocaine-induced locomotor sensitization test, the conditioned place preference paradigm or the operant self-administration paradigm. Additionally, they were also evaluated in the passive avoidance task, the tail-suspension and the splash tests. The results revealed that the females with lower PPI presented higher consequences of MSEW on the effects of cocaine and showed an increase in anhedonia-like behaviours. Our findings support that a PPI deficit could represent a biomarker of vulnerability to the effects of cocaine induced by MSEW.



中文翻译:

前脉冲抑制可以预测可卡因对母体分离雌性小鼠的激励作用

惊吓反应的前脉冲抑制 (PPI) 可以识别对可卡因的影响更敏感的啮齿动物。PPI 较低的小鼠更容易受到可卡因的影响,并且更容易患上物质使用障碍 (SUD)。早期断奶母体分离 (MSEW) 是一种相关的动物模型,可在整个生命过程中诱导动机改变。然而,只有少数关于女性的研究存在,尽管她们更容易受到压力和可卡因相关问题的影响。因此,本研究的目的是评估 PPI 识别更容易受到早期压力对可卡因激励作用的长期后果影响的女性的能力。雌性小鼠接受 MSEW 并根据其高或低 PPI 进行分类。然后在可卡因诱导的运动致敏试验、条件性位置偏好范式或操作性自我管理范式中对它们进行评估。此外,他们还在被动回避任务、尾部悬挂和飞溅测试中进行了评估。结果表明,具有较低 PPI 的女性对 MSEW 对可卡因的影响表现出更高的后果,并表现出类似快感缺乏的行为的增加。我们的研究结果支持 PPI 缺陷可能代表易受 MSEW 诱导的可卡因影响的生物标志物。结果表明,具有较低 PPI 的女性对 MSEW 对可卡因的影响表现出更高的后果,并表现出类似快感缺乏的行为的增加。我们的研究结果支持 PPI 缺陷可能代表易受 MSEW 诱导的可卡因影响的生物标志物。结果表明,具有较低 PPI 的女性对 MSEW 对可卡因的影响表现出更高的后果,并表现出类似快感缺乏的行为的增加。我们的研究结果支持 PPI 缺陷可能代表易受 MSEW 诱导的可卡因影响的生物标志物。

更新日期:2021-08-26
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