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Opto-chemical treatment for enhanced high-level disinfection of mature bacterial biofilm in a Teflon-based endoscope model
Biomedical Optics Express ( IF 3.4 ) Pub Date : 2021-08-23 , DOI: 10.1364/boe.434047
Van Nam Tran 1, 2 , Periaswamy Sivagnanam Saravana 2, 3 , Suhyun Park 4 , Van Gia Truong 1 , Byung-Soo Chun 3 , Hyun Wook Kang 1, 5
Affiliation  

Medical societies and public health agencies rigorously emphasize the importance of adequate disinfection of flexible endoscopes. The aim of this work was to propose a novel opto-chemical disinfection treatment against Staphylococcus aureus grown in mature biofilm on Teflon-based endoscope channel models. Laser irradiation using near-infrared and blue wavelengths combined with a low concentration of chemical disinfectant induced both irreversible thermal denaturation and intercellular oxidative stress as a combined mechanism for an augmented antimicrobial effect. The opto-chemical method yielded a 6.7–log10 reduction of the mature Staphylococcus aureus biofilms (i.e., approximately 1.0-log10 higher than current requirement of standard treatment). The proposed technique may be a feasible disinfection method for mitigating the risk associated with infection transmission.

中文翻译:

在基于聚四氟乙烯的内窥镜模型中用于增强成熟细菌生物膜的高水平消毒的光化学处理

医学会和公共卫生机构严格强调对软性内窥镜进行充分消毒的重要性。这项工作的目的是提出一种针对在基于聚四氟乙烯的内窥镜通道模型上成熟生物膜中生长的金黄色葡萄球菌的新型光化学消毒处理方法。使用近红外和蓝色波长的激光照射与低浓度化学消毒剂相结合,可诱导不可逆的热变性和细胞间氧化应激,作为增强抗菌作用的联合机制。光化学方法使成熟的金黄色葡萄球菌生物膜减少了 6.7-log 10(即大约 1.0-log 10高于目前的标准治疗要求)。所提出的技术可能是一种可行的消毒方法,可减轻与感染传播相关的风险。
更新日期:2021-09-02
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