The arterial resistance vasculature modulates blood pressure and flow to match oxygen delivery to tissue metabolic demand. As such, resistance arteries and arterioles have evolved a series of highly orchestrated cell-cell communication mechanisms between endothelial cells and vascular smooth muscle cells to regulate vascular tone. In response to neurohormonal agonists, release of several intracellular molecules, including nitric oxide, evokes changes in vascular tone. We and others have uncovered novel redox switches in the walls of resistance arteries that govern nitric oxide compartmentalization and diffusion. In this review, we discuss our current understanding of redox switches controlling nitric oxide signaling in endothelial and vascular smooth muscle cells, focusing on new mechanistic insights, physiological and pathophysiological implications, and advances in therapeutic strategies for hypertension and other diseases.

中文翻译：

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控制阻力血管系统中一氧化氮信号传导的氧化还原开关及其对血压调节的影响：2020 年职业生涯中期卓越研究奖

动脉阻力脉管系统调节血压和流量以使氧气输送与组织代谢需求相匹配。因此，阻力动脉和小动脉在内皮细胞和血管平滑肌细胞之间进化出一系列高度协调的细胞间通讯机制，以调节血管张力。作为对神经激素激动剂的反应，包括一氧化氮在内的几种细胞内分子的释放会引起血管张力的变化。我们和其他人在控制一氧化氮区室化和扩散的阻力动脉壁中发现了新的氧化还原开关。在这篇综述中，我们讨论了我们目前对控制内皮和血管平滑肌细胞中一氧化氮信号传导的氧化还原开关的理解，重点关注新的机制见解，