As the most common cause of dementia, Alzheimer’s disease (AD) is progressively neurodegenerative disease. In the initial stage, Alzheimer's disease is related to the memory disorder, followed by a serious progressive decline in cognitive function, and finally died. Neurofibrillary tangles (NFTs) deposited in neurons form one of the histopathological features of AD. NFTs are composed of abnormally modified forms, such as hyperphosphorylation, of tau protein. DNA methylation on Tau protein related genes in the brains of AD patients plays an important role in AD pathogenesis. In this paper, the process and role of gene methylation in abnormal Tau modification and aggregation in the development of Alzheimer's disease were discussed. The effect of DNA methylation on tau protein in the brain of patients with Alzheimer's disease will help to find new targets in the development of drugs for treating Alzheimer's disease.

作为痴呆的最常见原因，阿尔茨海默病（AD）是进行性神经退行性疾病。阿尔茨海默病初期与记忆障碍有关，随后认知功能严重进行性下降，最后死亡。沉积在神经元中的神经原纤维缠结 (NFT) 是 AD 的组织病理学特征之一。NFT 由 tau 蛋白的异常修饰形式（例如过度磷酸化）组成。AD患者脑内Tau蛋白相关基因的DNA甲基化在AD发病机制中起重要作用。本文就基因甲基化在阿尔茨海默病发展过程中异常Tau修饰和聚集的过程及作用进行了探讨。DNA甲基化对阿尔茨海默病患者大脑tau蛋白的影响