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Rodent models used in preclinical studies of deep brain stimulation to rescue memory deficits
Neuroscience & Biobehavioral Reviews ( IF 8.2 ) Pub Date : 2021-08-23 , DOI: 10.1016/j.neubiorev.2021.08.012
Matthieu Faillot 1 , Antoine Chaillet 2 , Stéphane Palfi 1 , Suhan Senova 1
Affiliation  

Deep brain stimulation paradigms might be used to treat memory disorders in patients with stroke or traumatic brain injury. However, proof of concept studies in animal models are needed before clinical translation. We propose here a comprehensive review of rodent models for Traumatic Brain Injury and Stroke. We systematically review the histological, behavioral and electrophysiological features of each model and identify those that are the most relevant for translational research.



中文翻译:

用于脑深部刺激的临床前研究以挽救记忆缺陷的啮齿动物模型

深部脑刺激范例可用于治疗中风或创伤性脑损伤患者的记忆障碍。然而,在临床转化之前,需要在动物模型中进行概念研究的证明。我们在此建议对创伤性脑损伤和中风的啮齿动物模型进行全面审查。我们系统地审查了每个模型的组织学、行为和电生理特征,并确定了与转化研究最相关的特征。

更新日期:2021-09-17
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