Zinc finger proteins (ZFPs) are a large diverse family of proteins with one or more zinc finger domains in which zinc is important in stabilising the domain. ZFPs can interact with DNA, RNA, lipids or even other proteins and therefore contribute to diverse cellular processes including transcriptional regulation, ubiquitin-mediated protein degradation, mRNA decay and stability. In this review, we provide the first comprehensive classification of ZFPs of the malaria parasite Plasmodium falciparum and provide a state of knowledge on the main ZFPs in the parasite, which include the C2H2, CCCH, RING finger and the PHD finger proteins.

中文翻译：

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恶性疟原虫的锌指蛋白

锌指蛋白 (ZFP) 是一个大而多样的蛋白质家族，具有一个或多个锌指结构域，其中锌在稳定结构域中起重要作用。ZFP 可以与 DNA、RNA、脂质甚至其他蛋白质相互作用，因此有助于多种细胞过程，包括转录调节、泛素介导的蛋白质降解、mRNA 衰变和稳定性。在这篇综述中，我们首次对疟原虫恶性疟原虫的 ZFP 进行了全面分类，并提供了对该寄生虫中主要 ZFP 的认识状态，包括 C2H2、CCCH、RING 指和 PHD 指蛋白。