This article presents the design, synthesis and characterization of a series of new acetylenic bis-chalcones (5a-5c) and chalcone functionalized 1,2,3-triazole allied bis-organosilanes (6a-6c) using aldol condensation followed by the Cu(I) catalyzed click strategy. The absorption studies of the designed compounds 5a and 6a were examined towards various metal ions that exhibit their high selectivity and sensitivity towards the recognition of Sn²⁺ and Hg²⁺ ions. The sensors show reversible nature upon the addition of disodium salt of ethylenediaminetetraacetic acid. Furthermore, the obtained detection limit with sensors 5a and 6a by plotting calibration curve was 0.34 µM and 0.64 µM for Sn²⁺ ion and 0.31 µM and 0.15 µM for Hg²⁺ ion respectively. The association constant value calculated for chemosensors 5a and 6a using the Benesi and Hildebrand plot method was 0.69 × 10⁵ M⁻¹ and 0.18 × 10⁵ M⁻¹ towards Sn²⁺ ion and 0.67 × 10⁶ M⁻¹ and 0.54 × 10⁶ M⁻¹ towards Hg²⁺ ion respectively. Moreover, the synthesized compounds 5a and 6a were investigated for their biological application by evaluating their cytotoxicity and antioxidant activity.

本文介绍了一系列新的炔属双查耳酮 ( 5a-5c ) 和查耳酮官能化的 1,2,3-三唑类双有机硅烷 ( 6a-6c )的设计、合成和表征，使用羟醛缩合和 Cu( I) 催化点击策略。设计的化合物5a和6a对各种金属离子的吸收研究进行了检查，这些金属离子对 Sn ²⁺和 Hg ²⁺离子的识别表现出高选择性和敏感性。在加入乙二胺四乙酸的二钠盐后，传感器显示出可逆性质。此外，使用传感器5a和6a获得的检测限通过绘制校准曲线为0.34μM和0.64μM用户需要Sn ²⁺离子和0.31μM和0.15μM对Hg ²⁺分别离子。使用 Benesi 和 Hildebrand 绘图方法计算的化学传感器5a和6a的关联常数值为0.69 × 10 ⁵ M ^-1和 0.18 × 10 ⁵ M ^-1对 Sn ²⁺离子和 0.67 × 10 ⁶ M ^-1和 0.54 × 10 ⁶ M ^-1分别朝向 Hg ²⁺离子。此外，合成的化合物5a和6a 通过评估它们的细胞毒性和抗氧化活性来研究它们的生物学应用。