Abstract

This work presents the synthesis, structural investigation, and some properties of a new PLA-Siloxane-PEO hybrid featuring covalent bonds between polymers and siloxane nodes. The synthesis simultaneously connecting PLA and PEO chains directly to the inorganic phase is first achieved through the use of sol–gel process. The structural features, thermal properties and chemical stability of this biocompatible system have been studied by Fourier-transform infrared spectroscopy (FTIR), Raman spectroscopy, ²⁹Si Nuclear Magnetic Resonance (NMR), scanning electron microscopy (MEV), X-ray diffraction (XRD), small-angle X-ray scattering (SAXS), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). SEM and SAXS measurements showed that the siloxane nodes act as crosslinks between the polymer chains promoting high miscibility between PLA and PEO. FTIR, Raman XRD, DSC, and TGA showed that the presence of the siloxane nodes diminishes the crystallinity of both polymers and increases their thermal resistance. In addition to the absence of brittleness due to the low crystalline character of PLA, this new material exhibits a fantastic resistance to PLA degradation in aqueous medium, attributed both to the presence of the siloxane particles acting as a barrier towards water diffusion and to the hydrophilic PEO segments which may attract water molecules, preventing PLA hydrolysis. All of these characteristics offer an amazing perspective for the use of this hybrid material in biological, medical, and pharmaceutical applications.

中文翻译：

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具有增强的热性能和水解稳定性的新型溶胶-凝胶衍生的 PLA-硅氧烷-PEO 纳米复合材料

摘要

这项工作介绍了一种新型 PLA-硅氧烷-PEO 杂化物的合成、结构研究和一些特性，其特征在于聚合物和硅氧烷节点之间的共价键。将 PLA 和 PEO 链同时直接连接到无机相的合成首先是通过使用溶胶-凝胶工艺实现的。已经通过傅里叶变换红外光谱 (FTIR)、拉曼光谱、²⁹研究了这种生物相容性系统的结构特征、热性能和化学稳定性Si 核磁共振 (NMR)、扫描电子显微镜 (MEV)、X 射线衍射 (XRD)、小角 X 射线散射 (SAXS)、热重分析 (TGA) 和差示扫描量热法 (DSC)。SEM 和 SAXS 测量表明，硅氧烷节点充当聚合物链之间的交联，促进了 PLA 和 PEO 之间的高混溶性。FTIR、拉曼 XRD、DSC 和 TGA 表明，硅氧烷节点的存在降低了两种聚合物的结晶度并增加了它们的耐热性。除了由于 PLA 的低结晶特性而没有脆性外，这种新材料还表现出极好的抗 PLA 在水性介质中降解的能力，这归因于硅氧烷颗粒的存在，作为水扩散的屏障，以及亲水性 PEO 链段可能吸引水分子，防止 PLA 水解。所有这些特性为这种混合材料在生物、医学和制药应用中的使用提供了一个惊人的前景。