FKBP5 gene–environment interaction (cG × E) studies have shown diverse results, some indicating significant interaction effects between the gene and environmental stressors on depression, while others lack such results. Moreover, FKBP5 has a potential role in the diathesis stress and differential susceptibility theorem. The aim of the present study was to evaluate whether a cG × E interaction effect of FKBP5 single-nucleotide polymorphisms (SNPs) or haplotype and early life stress (ELS) on depressive symptoms among young adults was moderated by a positive parenting style (PASCQ^pos), through the frameworks of the diathesis stress and differential susceptibility theorem. Data were obtained from the Survey of Adolescent Life in Västmanland Cohort Study, including 1006 participants and their guardians. Data were collected during 2012, when the participants were 13 and 15 years old (Wave I: DNA), 2015, when participants were 16 and 18 years old (Wave II: PASCQ^pos, depressive symptomology and ELS) and 2018, when participants were 19 and 21 years old (Wave III: depressive symptomology). Significant three-way interactions were found for the FKBP5 SNPs rs1360780, rs4713916, rs7748266 and rs9394309, moderated by ELS and PASCQ^pos, on depressive symptoms among young adults. Diathesis stress patterns of interaction were observed for the FKBP5 SNPs rs1360780, rs4713916 and rs9394309, and differential susceptibility patterns of interaction were observed for the FKBP5 SNP rs7748266. Findings emphasize the possible role of FKBP5 in the development of depressive symptoms among young adults and contribute to the understanding of possible differential susceptibility effects of FKBP5.

FKBP5基因 - 环境相互作用（cG × E）研究显示了不同的结果，一些表明基因和环境压力因素对抑郁症的相互作用有显着影响，而另一些则缺乏这样的结果。此外，FKBP5在素质应力和微分磁化率定理中具有潜在作用。本研究的目的是评估FKBP5单核苷酸多态性 (SNP) 或单倍型和早期生活压力 (ELS) 对青少年抑郁症状的 cG × E 相互作用效应是否受到积极的养育方式 (PASCQ ^pos)，通过素质应力和微分磁化率定理的框架。数据来自西曼兰队列研究中的青少年生活调查，包括 1006 名参与者及其监护人。数据收集于 2012 年，参与者分别为 13 岁和 15 岁（第一波：DNA），2015 年，参与者分别为 16 和 18 岁（第二波：PASCQ ^pos，抑郁症状和 ELS）和 2018 年，当参与者19 岁和 21 岁（第三波：抑郁症状）。FKBP5 SNPs rs1360780、rs4713916、rs7748266和rs9394309发现了显着的三向相互作用，由 ELS 和 PASCQ ^pos调节，关于年轻人的抑郁症状。观察到FKBP5 SNP rs1360780、rs4713916和rs9394309相互作用的素质应力模式，并观察到​​FKBP5 SNP rs7748266相互作用的不同易感性模式。研究结果强调了FKBP5在年轻人抑郁症状发展中的可能作用，并有助于理解FKBP5可能的不同易感性影响。