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Hürthle Cell Carcinoma of the Thyroid Gland: Systematic Review and Meta-analysis
Advances in Therapy ( IF 3.8 ) Pub Date : 2021-08-22 , DOI: 10.1007/s12325-021-01876-7
Andrés Coca-Pelaz 1 , Juan P Rodrigo 1 , Jatin P Shah 2 , Alvaro Sanabria 3 , Abir Al Ghuzlan 4 , Carl E Silver 5 , Ashok R Shaha 2 , Peter Angelos 6 , Dana M Hartl 7, 8 , Antti A Mäkitie 9 , Kerry D Olsen 10 , Randall P Owen 11 , Gregory W Randolph 12 , Ricard Simó 13 , Ralph P Tufano 14 , Luiz P Kowalski 15 , Mark E Zafereo 14 , Alessandra Rinaldo 16 , Alfio Ferlito 17
Affiliation  

Introduction

Hürthle cell carcinoma (HCC) comprises about 5% of thyroid carcinoma cases. Partly because of its rarity there is much we still need to know about HCC as compared to other histological cancer subtypes.

Methods

We conducted a systematic literature review following PRISMA guidelines and meta-analysis, from 2000 to 2020, to investigate the main characteristics of HCC and clarify information concerning tumor behavior and treatment.

Results

Our review included data from 9638 patients reported in 27 articles over the past 20 years. This tumor occurred more frequently in women (67.5%). The mean age was 57.6 years, and the mean size of the neoplasm at diagnosis was 30 mm. Extrathyroidal extension was common (24%) but lymph node metastasis was not (9%). Total thyroidectomy was the most common surgical approach, with neck dissection usually performed in cases with clinically apparent positive neck nodes. Radioiodine therapy was frequently applied (54%), although there is no consensus about its benefits. The mean 5- and 10-year overall survival was 91% and 76%, respectively.

Conclusion

This review serves to further elucidate the main characteristics of this malignancy. HCC of the thyroid is rare and most often presents with a relatively large nodule, whereas lymph node metastases are rare. Given the rarity of HCC, a consensus on their treatment is needed, as doubts remain concerning the role of specific tumor findings and their influence on management.



中文翻译:

甲状腺 Hürthle 细胞癌:系统评价和 Meta 分析

介绍

Hürthle 细胞癌 (HCC) 约占甲状腺癌病例的 5%。部分因为它的罕见性,与其他组织学癌症亚型相比,我们仍然需要了解很多关于 HCC 的信息。

方法

我们按照 PRISMA 指南和荟萃分析从 2000 年到 2020 年进行了系统的文献回顾,以研究 HCC 的主要特征并阐明有关肿瘤行为和治疗的信息。

结果

我们的综述包括来自过去 20 年 27 篇文章中报告的 9638 名患者的数据。这种肿瘤在女性中更常见(67.5%)。平均年龄为 57.6 岁,诊断时肿瘤的平均大小为 30 毫米。甲状腺外转移常见(24%),但淋巴结转移不常见(9%)。甲状腺全切除术是最常见的手术方法,通常在临床明显阳性颈部淋巴结的病例中进行颈部清扫。经常使用放射性碘治疗 (54%),但对其益处尚未达成共识。平均 5 年和 10 年总生存率分别为 91% 和 76%。

结论

本综述旨在进一步阐明这种恶性肿瘤的主要特征。甲状腺的 HCC 很少见,通常表现为相对较大的结节,而淋巴结转移很少见。鉴于 HCC 的罕见性,需要就其治疗达成共识,因为对特定肿瘤发现的作用及其对治疗的影响仍存疑虑。

更新日期:2021-08-23
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