Background

Hypoglycemia frequently occurs in patients with sepsis. The status of prognosis of sepsis patients varies with the cause of hypoglycemia.

Objective

A meta-analysis was performed to obtain a reliable basis for assessing the severity of disease in sepsis patients.

Methods

A search of electronic databases was performed. The random-effects model was employed to calculate the overall odds ratio (OR) and 95% CI.

Results

Five cohort studies were included. Decreased blood glucose level was associated with an increased risk of death [OR:1.68; 95% CI (1.12–2.53)]. Incidents of mortality were analyzed based on the causative factor of hypoglycemia. Patients with spontaneous hypoglycemia showed a significantly higher mortality rate than the control subjects[OR 1.65; 95% CI (1.20–2.28); p = 0.002].

Conclusion

In the early stages of sepsis, the occurrence of spontaneous hypoglycemia may be associated with the severity of the disease.

中文翻译：

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脓毒症患者的低血糖和死亡率：系统评价和荟萃分析

背景

败血症患者经常发生低血糖。脓毒症患者的预后状况因低血糖原因而异。

客观的

进行荟萃分析以获得评估败血症患者疾病严重程度的可靠基础。

方法

进行了电子数据库的搜索。采用随机效应模型计算总体优势比 (OR) 和 95% CI。

结果

包括五项队列研究。血糖水平降低与死亡风险增加有关 [OR:1.68; 95% 置信区间 (1.12–2.53)]。根据低血糖的原因分析死亡事件。自发性低血糖患者的死亡率明显高于对照组[OR 1.65; 95% 置信区间 (1.20–2.28)；p  = 0.002]。

结论

在败血症的早期阶段，自发性低血糖的发生可能与疾病的严重程度有关。