Anxiety is being increasingly identified in Angelman syndrome (AS). Qualitative questions and quantitative assessments were used to evaluate for anxiety in 50 subjects with AS. In-person evaluations assessed behaviors concerning for anxiety and circumstances wherein they occurred. Caregivers completed anxiety and other behavioral rating scales. Caregiver responses were categorized and compared to items from anxiety rating scales. The most common behavioral manifestation of anxiety was "aggression." The most common circumstance was "separation from caregiver/parent." Subjects had elevated scores on anxiety, irritability and hyperactivity scales with lower mean scores among subjects with a maternal deletion. The Pediatric Anxiety Rating Scale best captured behaviors described by caregivers. Existing anxiety scales should be adapted for use in AS.

中文翻译：

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父母对 Angelman 综合征焦虑症的描述。

Angelman 综合征 (AS) 中越来越多地发现焦虑症。定性问题和定量评估用于评估 50 名 AS 受试者的焦虑情况。现场评估评估了与焦虑相关的行为和它们发生的情况。照顾者完成了焦虑和其他行为评定量表。照顾者的反应被分类并与焦虑等级量表中的项目进行比较。焦虑最常见的行为表现是“攻击性”。最常见的情况是“与照顾者/父母分离”。在母亲缺失的受试者中，受试者的焦虑、易怒和多动量表得分较高，平均得分较低。儿科焦虑评定量表最能捕捉照顾者描述的行为。