Redundancy is a ubiquitous property of the nervous system. This means that vastly different configurations of cellular and synaptic components can enable the same neural circuit functions. However, until recently, very little brain disorder research has considered the implications of this characteristic when designing experiments or interpreting data. Here, we first summarise the evidence for redundancy in healthy brains, explaining redundancy and three related sub-concepts: sloppiness, dependencies and multiple solutions. We then lay out key implications for brain disorder research, covering recent examples of redundancy effects in experimental studies on psychiatric disorders. Finally, we give predictions for future experiments based on these concepts.

中文翻译：

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脑部疾病中的神经回路功能冗余。

冗余是神经系统普遍存在的特性。这意味着细胞和突触组件的截然不同的配置可以实现相同的神经回路功能。然而，直到最近，在设计实验或解释数据时，很少有脑部疾病研究考虑到这一特征的含义。在这里，我们首先总结了健康大脑中冗余的证据，解释了冗余和三个相关的子概念：马虎、依赖和多种解决方案。然后，我们列出了对脑部疾病研究的关键影响，涵盖了最近在精神疾病实验研究中冗余效应的例子。最后，我们基于这些概念对未来的实验进行预测。