Well-described evidence has demonstrated the critical roles of aerobic glycolysis in triple-negative breast cancer (TNBC) oncotherapy. Moreover, next-generation high-throughput sequencing indicates the potential regulation of energy metabolism by circular RNAs (circRNAs) in TNBC. However, circRNA modulation of TNBC aerobic glycolysis is still unclear. Here, the present research aimed to investigate the function and underlying mechanisms of novel circPDCD11 (hsa_circ_0019853) in TNBC aerobic glycolysis. The results revealed that circPDCD11 expression was significantly upregulated in TNBC tissues and cells. Clinical data demonstrated that the high expression of circPDCD11 was closely correlated with a poor prognosis and acted as an independent risk factor for TNBC prognosis. Functionally, in vitro gain- and loss-of-function experiments revealed that circPDCD11 accelerated glucose uptake, lactate production, ATP generation, and the extracellular acidification rate in TNBC cells. In vivo, circPDCD11 silencing repressed tumor growth. Mechanistically, circPDCD11 acted as a miRNA sponge to enhance LDHA expression by sponging miR-432-5p. In conclusion, these combined results demonstrated that circPDCD11 acts as an oncogene for TNBC, providing a promising prognostic biomarker for TNBC.

充分描述的证据已经证明了有氧糖酵解在三阴性乳腺癌 (TNBC) 肿瘤治疗中的关键作用。此外，下一代高通量测序表明 TNBC 中环状 RNA (circRNAs) 对能量代谢的潜在调节。然而，circRNA 对 TNBC 有氧糖酵解的调节仍不清楚。在此，本研究旨在研究新型 circPDCD11 (hsa_circ_0019853) 在 TNBC 有氧糖酵解中的功能和潜在机制。结果表明，circPDCD11 表达在 TNBC 组织和细胞中显着上调。临床数据表明，circPDCD11的高表达与不良预后密切相关，是TNBC预后的独立危险因素。在功能上，体外功能获得和功能丧失实验表明，circPDCD11 加速了 TNBC 细胞的葡萄糖摄取、乳酸产生、ATP 生成和细胞外酸化率。在体内，circPDCD11沉默抑制了肿瘤生长。从机制上讲，circPDCD11 充当 miRNA 海绵，通过海绵 miR-432-5p 来增强 LDHA 表达。总之，这些综合结果表明 circPDCD11 作为 TNBC 的致癌基因，为 TNBC 提供了一个有希望的预后生物标志物。