Zinc-based biometal is expected to become a new generation of biodegradable implants. Due to its antibacterial and biocompatibility in vivo, zinc metals is recently considered to be the most promising biodegradable metal, However, cytotoxicity is the thorny problem that currently restrict its application, due to the excessive Zn ions released during degradation. In order to solve these problems, dopamine modified strontium-doped hydroxyapatite coating (SrHA/PDA) was fabricated on alkali-treated pure zinc to improve its corrosion rate and cytocompatibility by electrodeposition for the first time. The obtained coating showed a dense structure and high crystallinity, which was attributed to the attraction of Ca²⁺ ions by polydopamine. The results showed that the SrHA/PDA coating delayedthe degradation rate of zinc metal, which reduced the release of Zn²⁺, thereby reducing its cytotoxicity. Additionally, electrochemical tests showed that SrHA/PDA coating can reduce the corrosion rate of pure zinc. In vitro cell viability showed that even at high Zn²⁺ concentrations (3.11 mg/L), preosteoblasts (MC3T3-E1) cells proliferated at a high rate on SrHA/PDA, thus confirming that Sr²⁺ counteracted the cytotoxic effects of Zn²⁺ and promoted cell differentiation. Moreover, the SrHA/PDA coating still maintained excellent antibacterial effects against pathogenic bacterial strains (Escherichia coli and Staphylococcus aureus). Mild pH changes had no significant effect on the viability of cells and bacterias. Collectively, the present study elucidated that by coating SrHA/PDA/Zn(OH)₂ on Zn, a controllable corrosion rate, original antibacterial properties and better cell compatibility can be achieved. This provided a new strategy for the surface modification of biodegradable Zn.

锌基生物金属有望成为新一代生物降解植入物。由于其在体内的抗菌性和生物相容性，锌金属最近被认为是最有前途的可生物降解金属，但由于在降解过程中释放出过量的锌离子，细胞毒性是目前限制其应用的棘手问题。为了解决这些问题，首次在碱处理的纯锌上制备了多巴胺修饰的掺锶羟基磷灰石涂层（SrHA/PDA），以通过电沉积提高其腐蚀速率和细胞相容性。得到的涂层显示出致密的结构和高结晶度，这归因于 Ca ²⁺的吸引力聚多巴胺离子。结果表明，SrHA/PDA涂层延迟了锌金属的降解速度，从而减少了Zn ²⁺的释放，从而降低了其细胞毒性。此外，电化学测试表明 SrHA/PDA 涂层可以降低纯锌的腐蚀速率。体外细胞活力表明，即使在高 Zn ²⁺浓度 (3.11 mg/L) 下，前成骨细胞 (MC3T3-E1) 细胞在 SrHA/PDA 上仍以高速率增殖，从而证实 Sr ²⁺抵消了 Zn ²的细胞毒性作用⁺并促进细胞分化。此外，SrHA/PDA 涂层对病原菌（大肠杆菌和金黄色葡萄球菌）。轻微的 pH 值变化对细胞和细菌的活力没有显着影响。总的来说，本研究表明，通过在 Zn 上涂覆 SrHA/PDA/Zn(OH) ₂，可以获得可控的腐蚀速率、原始的抗菌性能和更好的细胞相容性。这为可生物降解锌的表面改性提供了新的策略。