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Manganese body burden in children is associated with reduced visual motor and attention skills
Neurotoxicology and Teratology ( IF 2.9 ) Pub Date : 2021-08-21 , DOI: 10.1016/j.ntt.2021.107021
Lonnie Sears 1 , John V Myers 2 , Clara G Sears 3 , Guy N Brock 2 , Charlie Zhang 4 , Kristina M Zierold 5
Affiliation  

Manganese (Mn) is an essential element, however, children with moderate to high Mn exposure can exhibit neurobehavioral impairments. One way Mn appears to affect brain function is through altering dopaminergic systems involved with motor and cognitive control including frontal – striatal brain systems. Based on the risk for motor and attention problems, we evaluated neurobehavioral function in 255 children at risk for Mn exposure due to living in proximity to coal ash storage sites. Proton Induced X-ray Emissions (PIXE) analysis was conducted on finger and toenails samples. Multiple neuropsychological tests were completed with the children. Fifty-five children had Mn concentrations above the limit of detection (LOD) (median concentration = 3.95 ppm). Children with detectable Mn concentrations had reduced visual motor skills (β = −5.62, CI: −9.11, −2.12, p = 0.008) and more problems with sustained attention, based on incorrect responses on a computerized attention test, (β = 0.40, CI: 0.21, 0.59, p < 0.001) compared with children who had Mn concentrations below the LOD. Findings suggest that Mn exposure impacts attention and motor control possibly due to neurotoxicity involving basal ganglia and forebrain regions. Visual-motor and attention tests may provide a sensitive measure of Mn neurotoxicity, useful for evaluating the effects of exposure in children and leading to better treatment options.



中文翻译:

儿童体内锰负担与视觉运动和注意力技能下降有关

锰 (Mn) 是一种必需元素,但是,中度至高锰暴露的儿童可能会出现神经行为障碍。锰影响大脑功能的一种方式是通过改变与运动和认知控制有关的多巴胺能系统,包括额叶-纹状体大脑系统。根据运动和注意力问题的风险,我们评估了 255 名因居住在煤灰储存地点附近而面临锰暴露风险的儿童的神经行为功能。对手指和脚趾甲样本进行质子诱导 X 射线发射 (PIXE) 分析。与孩子们一起完成了多项神经心理学测试。55 名儿童的锰浓度超过检测限 (LOD)(中位浓度 = 3.95 ppm)。 根据计算机注意力测试的错误反应,可检测到锰浓度的儿童视觉运动技能下降(β = -5.62,CI:-9.11,-2.12,p = 0.008),并且持续注意力方面存在更多问题(β = 0.40, 与锰浓度低于 LOD 的儿童相比,CI:0.21、0.59、p < 0.001)。研究结果表明,锰暴露会影响注意力和运动控制,可能是由于涉及基底神经节和前脑区域的神经毒性。视觉运动和注意力测试可以提供锰神经毒性的灵敏测量,有助于评估接触对儿童的影响并导致更好的治疗选择。

更新日期:2021-08-26
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