Background

Physical performance decline associated with aging is clinically important in the development of disability in the older population. More recently, procollagen type III N-terminal peptide (P3NP) and synaptosomal-associated protein of 25 kDa (SNAP25) have been suggested as potential biomarkers for physical performance decline.

Objective

The objective of this pilot study was to examine plasma P3NP and SNAP25 levels in relation to muscle mass, strength, and performance status, and to investigate the association of plasma P3NP and SNAP25 levels with sarcopenia components.

Methods

Seventy-nine community-dwelling elderly men (mean age: 78.1 ± 3.5 years) were randomly selected and matched by age from the Korean Frailty and Aging Cohort Study. The sample was classified into the “normal,” “low muscle mass only,” “sarcopenia,” and “low physical performance only” groups according to the criteria of the Asian Working Group for Sarcopenia 2019. Estimates and 95% confidence intervals (CIs) of log P3NP and log SNAP25 levels by muscle mass, strength, and performance status were obtained using a generalized linear model. Pearson correlations and multiple linear regression analyses were used to assess the association of log P3NP and log SNAP25 levels with appendicular skeletal muscle mass (ASM) index, handgrip strength, and physical performance.

Results

Log P3NP levels tended to be associated with low physical performance compared with the normal group (estimate = 0.54; 95% CI = −0.05, 1.14; p = 0.072). Log P3NP levels were inversely associated with physical performance (short physical performance battery and five-times sit-to-stand test) after adjusting for potential confounders (all p < 0.05) and tended to have an inverse association with gait speed (p = 0.078). Log P3NP levels tended to have a positive correlation with the ASM index (r² = 0.042; p = 0.070), but not with handgrip strength (r² = 0.0009; p = 0.795). However, no significant association between plasma SNAP25 levels and physical performance was observed.

Conclusion

Plasma P3NP levels might be a potential biomarker for decreased physical performance in elderly men. Further studies with larger sample sizes are needed to confirm our findings.

中文翻译：

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老年男性血浆 III 型前胶原 N 端肽 (P3NP) 水平与身体机能之间的关联：韩国虚弱和衰老队列研究 (KFACS)

背景

与衰老相关的身体机能下降在临床上对老年人群的残疾发展具有重要意义。最近，III 型前胶原 N 端肽 (P3NP) 和 25 kDa 的突触体相关蛋白 (SNAP25) 被认为是身体机能下降的潜在生物标志物。

客观的

这项初步研究的目的是检查血浆 P3NP 和 SNAP25 水平与肌肉质量、力量和性能状态的关系，并研究血浆 P3NP 和 SNAP25 水平与肌肉减少症成分的关联。

方法

79 名居住在社区的老年男性（平均年龄：78.1 ± 3.5 岁）是从韩国虚弱和老龄化队列研究中随机选择并按年龄匹配的。根据 2019 年亚洲肌肉减少症工作组的标准，将样本分为“正常”、“仅低肌肉量”、“肌肉减少症”和“仅低体能”组。估计值和 95% 置信区间 (CI) ) 的 log P3NP 和 log SNAP25 水平的肌肉质量、力量和性能状态是使用广义线性模型获得的。Pearson 相关性和多元线性回归分析用于评估 log P3NP 和 log SNAP25 水平与附肢骨骼肌质量 (ASM) 指数、握力和身体表现的关联。

结果

与正常组相比，Log P3NP 水平往往与低身体表现相关（估计值 = 0.54；95% CI = -0.05, 1.14；p  = 0.072）。在调整潜在混杂因素（所有p  < 0.05）后，Log P3NP 水平与身体表现（短期身体表现电池和五次坐到站立测试）呈负相关，并且倾向于与步态速度呈负相关（p  = 0.078 ）。Log P3NP 水平往往与 ASM 指数呈正相关（r ²  = 0.042；p  = 0.070），但与握力无关（r ²  = 0.0009；p = 0.795）。然而，没有观察到血浆 SNAP25 水平与身体机能之间的显着关联。

结论

血浆 P3NP 水平可能是老年男性身体机能下降的潜在生物标志物。需要更大样本量的进一步研究来证实我们的发现。