Novel gelators based on isomeric pyridine-hydrazide derivatives, namely, G1, G2, and G3 were successfully synthesized and characterized, among which G2 significantly surpassed G1 and G3, indicating that the position of the pyridine nitrogen remarkably affected the resulting gelation properties. Most interestingly, G2 was utilized as a naked eye chemosensor for many analytes such as F⁻, Cu²⁺, and Fe³⁺. Among the tested anions, only F⁻ showed a notable change from transparent gel to white emulsion. And the detection limit of G2 for F⁻ is 8.483 × 10⁻⁶ M. Among the tested metal ions, G2-DCM gel could enrich Cu²⁺ or Fe³⁺ in water resources by forming stable metallogels. Furthermore, the different color changed in the organogel-to-metallogel transformation process could be also observed. Hence, the G2-DCM gel could act as a multi-stimuli-responsive sensor for detecting F⁻, Cu²⁺, and Fe³⁺, and a promising smart soft material for enriching Cu²⁺ or Fe³⁺ in water resources.

成功合成并表征了基于异构吡啶-酰肼衍生物的新型凝胶剂，即G1、G2和G3，其中G2显着超过G1和G3，表明吡啶氮的位置显着影响了所得的凝胶化性能。最有趣的是，G2被用作许多分析物的裸眼化学传感器，例如 F ^-、Cu ²⁺和 Fe ³⁺。在测试的阴离子中，只有 F ^-表现出从透明凝胶到白色乳液的显着变化。和G2的检出限对于F ^-为8.483 × 10 ^-6  M。在测试的金属离子中，G2- DCM凝胶可以通过形成稳定的金属凝胶来富集水资源中的Cu ²⁺或Fe ³⁺。此外，还可以观察到在有机凝胶到金属凝胶转化过程中的不同颜色变化。因此，G2- DCM凝胶可以作为检测F ^-、Cu ²⁺和Fe ³⁺的多刺激响应传感器，以及用于富集水资源中的Cu ²⁺或Fe ³⁺的有前途的智能软材料。